Immune Chapters

Question 1

Salicylates (I)

Answer 1

Aspirin
Treatment of mild to moderate pain, fever, inflammatory conditions; reduction of risk of transient ischemic attack or stroke; reduction of risk of myocardial infarction

Question 2

Salicylates (A)

Answer 2

Inhibits the synthesis of prostaglandins; blocks the effects of pyrogens at the hypothalamus; inhibits platelet aggregation by blocking thromboxane A2

Question 3

Salicylates (CI - DD)

Answer 3

CI:
Tartrazine
bleeding abnormalities
Chicken pox or influenza (reye syndrome in children and teenagers)
procedures schedules within 1 week
history of nasal polyps, asthma, chronic urticara.

D-D:
many cus of the alteration on absorption, and effects on the liver

Question 4

Salicylates (AE)

Answer 4

Salicylism
confusion
tinnitus
acidosis
occult blood loss
GI discomfort

Question 5

NSAID (I - A)

Answer 5

Ibuprofen

Relief of signs and symptoms of rheumatoid arthritis and osteoarthritis; relief of mild to moderate pain;treatment of primary dysmenorrhea; fever reduction

Inhibits prostaglandin synthesis by blocking COX 1 and 2 receptor sites, leading to an anti-inflammatory effect, analgesia, and antipyretic effects.

Question 6

NSAID (CI - DD)

Answer 6

CI:
CV dysfunction
HTN
Peptic ulcer or known GI bleeding

DD:
Decreased diuretic effects if taken with loop diuretic
Decreased antiHTN effects if taken with beta blockers
Lithium toxicity with ibuprofen

Question 7

NSAID (AE)

Answer 7

Tinnitus
Somnolence
dyspepsia
bleeding

Question 8

Acetaminophen (I - A)

Answer 8

Tylenol
Treatment of mild to moderate pain, fever, or signs and symptoms of the common cold or flu. Musculoskeletal pain associated with arthritis and rheumatic disorders.

Acts directly on the hypothalamus to cause vasodilation and sweating, which will reduce fever; mechanism of action as an analgesic not understood.

Question 9

Acetaminophen (CI - DD)

Answer 9

CI:
Hepatic dysfunction
Chronic Alcoholism

DD:
Increased risk of bleeding with anticoags
alcohol
hepato-toxicity with barbiturates.

Question 10

Immune Stimulant (I - A)

Answer 10

Interferon alfa-2b

Hairy cell leukemia, malignant melanoma, AIDS-related kaposi sarcoma, chronic hep B, and C, intralesional treatment of condylomata acuminata in PT 18+

Inhibits the growth of tumor cells and enhances the immune response

Question 11

Immune Stimulant (CI - DD)

Answer 11

CI:
Women use condoms pls
Cardiac disease (HTN dysrhythmias reported)
Myelosupression
CNS dysfunction (CNS depression)

DD: none

Question 12

Immune Stimulant (AE)

Answer 12

Flu like syndrome
bone marrow suppression
depression
suicidal thoughts
liver impairment

Question 13

Interleukin (I - A)

Answer 13

Aldesleukin

Metastatic renal cell carcinoma in adults, treatment of metastatic melanomas (orphan drug use)

Activates human cellular immunity and inhibits tumor growth through increases in lymphocytes, platelets, and cytokines.

Question 14

Interleukin (CI - DD)

Answer 14

CI: allergy to E.coli
Women use condoms pls
CV impairment

DD: none

Question 15

Interleukin (AE)

Answer 15

Mental status changes, sinus tachycardia
arrhythmias, bone marrow supression
Resp. difficulties, hypotension

Question 16

T and B cell suppressors (I)

Answer 16

Cyclosporine

Prophylaxis for organ rejection in kidney, liver, and heart transplants (used with corticosteroids)

treatment of chronic rejection in patients previously treated with other immune suppressants, treatment of rheumatoid arthritis and recalcitrant psoriasis.

Question 17

T and B cell suppressors (A)

Answer 17

Reversibly inhibits immunocompetent lymphocytes; inhibits T helper cells and T suppressor cells, lymphokine production, and release of interleukin-2 and T cell growth factor .

Question 18

T and B cell suppressors (CI - DD)

Answer 18

CI: presence of known neoplasms

D-D: other drugs that are hepatotoxic or nephrotoxic

Question 19

T and B cell suppressors (AE):

Answer 19

increased risk for infection
tremor
HTN
gum hyperplasia
acne

Question 20

Vaccine

Answer 20

MMR ( Measles Mumps Rubella)

Active immunization against measles, mumps and rubella in children older than 15 months and adults

Attenuated MMR viruses produce a modified infection and stimulate an active immune reaction with the production of antibodies.

Question 21

MMR (CI - DD)

Answer 21

CI:
Immune deficiency
allergies to known components of the vaccine
who have received blood products in the last 3 months

DD: immunosuppressants

Question 22

MMR (AE):

Answer 22

Burning or stinging wheal or flare at the site of injection
rarely, febrile convulsions and high fever
guillain barre syndrome
ocular palsies