Chapter 35 - Hypothalamic and Pituitary Agents

Question 1

Leuprolide Indications

Answer 1

Indications:

Treatment of…

1. Advanced Prostatic Cancer
2. Endometriosis
3. Central percocious puberty
4. Uterine Leiomyomata

Question 2

Leuprolide Actions

Answer 2

GnRH agonists that occupies pituitary GnRH receptors and desensitizes them; causes an initial increase and then profound decrease in LH and FSH levels.

Question 3

Leuprolide Adverse Effects

Answer 3

Agonists can lead to increased release of sex hormones leading to ovarian overstimulation

hot flashes
MI
urinary frequency
hematuria 
People with peripheral vascular disorders

Question 4

Somatropin Indications

Answer 4

Growth Hormone Agonist

Long term treatment of children with growth failure associated with various deficiencies.
Girls with Turner’s syndrome, AIDS wasting and cachexia, GH deficiency in adults
Treatment of growth failure in children of small gestational age who do not achieve catch up growth by 2 years of age

Question 5

Somatropin Actions:

Answer 5

Replaces human GH, stimulates skeletal growth, growth of internal organs, and protein synthesis

Question 6

Somatropin Adverse Effects

Answer 6

Development of antibodies to growth hormone
insulin resistance
joint pain

Question 7

Somatropin Contraindications

Answer 7

Closed epiphyses
underlying cranial lesions
abdominal surgery
complications of open heart surgery

Question 8

Bromocriptine Indications

Answer 8

Growth Hormone Antagonist
Treatment of…
1. Treatment of Parkinson’s disease
2. Hyperprolactemia associated with pituitary adenomas
3. Female infertility associated with hyperprolactemia
4. Acromegaly

Question 9

Bromocriptine Actions

Answer 9

Acts directly on postsynaptic dopamine receptors in the brain

Question 10

Bromocriptine AE & D-D

Answer 10

Postural hypotension
Blocks lactation

Dont use with erythromycin or phenothiazines.