Chapter 28 - NMJ Blockers

Question 1

Pancuronium (I)

Answer 1

Non-depolarizing

As an adjunct to general anesthesia; to induce skeletal muscle relaxation; to reduce the intensity of muscle contractions in electroconvulsive therapy; to facilitate the care of patients undergoing mechanical ventilation

Question 2

Pancuronium (A)

Answer 2

Occupies the muscular cholinergic receptor site, preventing ACh from reacting with the receptor; does not cause activation of muscle cells; causes a flaccid paralysis

Question 3

Pancuronium (AE-CI-DD)

Answer 3

AE- Respiratory depression, apnea, cardiac arrhythmias
CI- myasthenia gravis, renal or hepatic disease, family history of malignant hyperthermia, caution w/ pulmonary or cardiovascular dysfunction, alter electrolyte and fluid imbalance, lactation
DDI- halogenated hydrocarbon anesthetics, Calcium-Channel blockers, xanthines, and alkaline solutions such as barbiturates, cholinesterase inhibitor

Question 4

Succinylcholine (I)

Answer 4

Depolarizing

As an adjunct to general anesthesia; to facilitate endotracheal intubation; to induce skeletal muscle relaxation during surgery or mechanical ventilation

Question 5

Succinylcholine (A)

Answer 5

Combines with ACh receptors at the motor endplate to produce depolarization; this inhibits neuromuscular transmission, causing a flaccid paralysis

Question 6

Succinylcholine (CI)

Answer 6

fractures, narrow angle glaucoma or penetrating eye injuries, genetic or disease-related conditions, low plasma cholinesterase.