Chapter 36 - Adrenocortical Agents

Question 1

Prednisone (I)

Answer 1

Glucocorticoids

Replacement therapy in adrenal cortical insufficiency
short term management of various inflammatory and allergic disorders
hypercalcemia ass. with cancer
hematological disorders
they give the body a chance to heal from the effects of inflammation
MORE ON PG. 581

Question 2

Prednisone (A)

Answer 2

Enters target cells and binds to intracellular corticosteroid receptors, initiating many complex reactions responsible for its antinflammatory and immunosuppressive effects.

Question 3

Prednisone (AE)

Answer 3

Sodium and fluid retention, amenorrhea
weight gain, immunosuppression
aggravation or masking of infections
impaired wound healing

Question 4

Prednisone (D-D) & (CI)

Answer 4

CI:
Presence of acute infections
Diabetes (glucose elevating effects)
Acute peptic ulcers

D-D: Erythromycin

Question 5

Fludrocortisone (I)

Answer 5

Mineralcorticoids

Partial replacement therapy in cortical insufficiency conditions
Treatment of salt-losing adrenogenital syndrome
Offlabel:
Hypotension

Question 6

Fludrocortisone (A)

Answer 6

Mineralcorticoids

Increases sodium reabsorption in the renal tubules, and increases potassium and hydrogen excretion leading to water and sodium retention

Question 7

Fludrocortisone (AE)

Answer 7

Frontal and occipital headaches
arthralgia
increased blood volume
anaphylaxis

Question 8

Fludrocortisone (CI & D-D)

Answer 8

Severe hypertension
HF, Cardiac disease (^BP)
Presence of any infection, high sodium intake

Dont use with anticholinesterases