Human disease L28: Biologics

Question 1

Biologics are composed of three types of drugs, what are they?

Answer 1

Cytokines

Fusion proteins

monoclonal antibodies

Question 2

why do biologics not elicit an immune respone?

Answer 2

because they do not carry any antigenic segments.

Question 3

is erythropoietin a cytokine

Answer 3

yes

Question 4

is a glycoprotein cytokine secreted mainly by the ………………… in response to cellular hypoxia; it stimulates red blood cell production in the bone marrow

Answer 4

kidney

Question 5

are proteins created through the joining of two or more genes that originally coded for separate proteins. Translation of this fusion gene results in a single or multiple polypeptides with functional properties derived from each of the original proteins

what is the name of the protein

Answer 5

fusion proteins

Question 6

what type of antibodies target a specific antigen

Answer 6

monoclonal antibodies

Question 7

there are four types of monoclonal antibodies, what are they

Answer 7

murine: entirely derived from a murine source. they can lead lead to an allergic reaction in humans.

Chimeric: the variable regions are of murine origins whereas the constant regions are human. these can also cause an allergy

Humanized: mostly derived fromm a human source except for the part of the antibody which binds to its target

Human: entirely derived from a human source

Question 8

which monoclonal antibody is completely derived from a mice or related rodent

Answer 8

murine antibody

Question 9

which monoclonal antibody has its variable regions derived from murine origins, whereas the constant regions are human

Answer 9

chimeric

Question 10

which monoclonal antibody is mostly derived from a human source except for the part of the antibody which binds to its target

Answer 10

humanized

Question 11

which monoclonal antibody is entirely derived from a human source

Answer 11

human - monoclonal antibody

Question 12

how many failed therapy must a patient have with DMARDS in order to be put on monoclonal antibody therapy

Answer 12

at least two DMARDS

Question 13

under what condition can a patient skip DMARDs and go straight to monoclonal antibody therapy

Answer 13

patients with severe Rheumatoid Arthritis

Question 14

adalimumab

certolizumab

infliximab

golimumab

the drugs listed above end with MAB, what does this mean

Answer 14

they are all Monoclonal AntiBodies