Human disease L26: Dobson lecture pt1 Autoimmunity and Corticosteroids Flashcards
type 1 diabetes is an autoimmune disease. where do the T cells attack in this condition
T cells attack and destroy the B cells in the pancreas that produce insulin.
what is autoimmune haemolytic anaemia
Autoimmune haemolytic anaemia is a type of anaemia that develops when the antibodies of a person’s immune system damage some of their red blood cells.
what is Immune thrombocytopenic purpura
Immune thrombocytopenic purpura (ITP) is a blood disorder characterized by a decrease in the number of platelets in the blood.
what is coeliac disease
Coeliac disease is a condition where your immune system attacks your own tissues when you eat gluten. This damages your gut (small intestine) so you are unable to take in nutrients.
what do DMARDS stand for
disease modifying anti-rheumatic drugs
what is the main function of DMARDS
supress the immune system
how do biologic DMARDS differ to onventional DMARDS
conventional DMARDS supress the entire immune system
biologic DMARDS target one aspect of the immune system
why do biologics DMARDS need to be adminstered through IV instead of orally
because they are protein, your stomach would digest them.
Corticosteroids suppress the multiple inflammatory genes that are activated in chronic inflammatory diseases, such as asthma, mainly by reversing histone acetylation of activated inflammatory genes through binding on what receptor
liganded glucocorticoid receptors (GR)
At higher concentrations of corticosteroids GR homodimers also interact with DNA recognition sites to active transcription of what?
anti-inflammatory genes
