HMP Shunt (Pentose Phosphate Pathway) Flashcards
The HMP shunt occur in the cytosol of which tissues
cytosol of: Liver, adipose tissue, lactating mammary gland, adrenal cortex, testes, ovaries, erytrhocytes, leukocytes
Which of the two phases of the HMP shunt is irreversible
oxidative phase (first phase)
the coenzyme NADP is derived from which vitamin
vitamin B complex (niacin)
What is the regulatory enzyme in the oxidative phase of the HMP shunt
Glucose-6-P. Dehydrogenase
Which molecule is a negative regulator for Glucose-6-P. Dehydrogenase
NADPH
Which molecule acts as an inducer of the gene to produce Glucose-6-P. Dehydrogenase
Insulin
What are the enzymes needed in the non oxidative phase of the HMP shunt
isomerase, an epimerase , transketolase and transaldolase
A low activity of which RBC enzyme can be an indication of thiamine deficiency
transketolase
Which two molecules facilitate the integration between the HMP shunt and glycolysis
Fructose-6P and glyceraldehyde 3P
NADPH from the HMP shunt is needed to maintain which molecule in its reduced state to be an antioxidant
glutathione
glutathione is a requirement for which enzyme
glutathione peroxidase
Which biosynthetic reactions are NADPH needed for
fatty acid and cholesterol biosynthesis
Which vasodilator is NADPH needed for its synthesis
nitric oxide
NADPH is need for hydroxylation of
cytochrome P-450
NADPH in the presence of NADPH oxidase is needed during which process
phagocytosis
NADPH oxidase deficiency is seen in which diseases
Chronic granulomatous disease (granulomas)
Deficiency of NADPH makes phagocytic cells incapable of producing superoxide which results in a negative ______ test
NBT (nitroblue tetrazolium) test
HMP shunt is needed for the production of _______ to make PRPP
Ribose-5-phosphate
Deficiency in which enzyme causes decrease NADPH which leads to hemolysis
Glu-6-P dehydrogenase deficiency
Person with Glu-6-P dehydrogenase deficiency are resistant to which deisease
malaria
Malaria is caused by which parasite
plasmodium falciparum
patients with Glu-6-P dehydrogenase deficiency are cautioned to avoid drugs that cause _____ stress
oxidative stress
Glu-6-P dehydrogenase deficiency is a major cause of which kind of anemia
hemolytic anemia
features of Glu-6-P dehydrogenase deficiency
Hemolytic anemia, hemolytic jaundice,
decreased level of reduced glutathione, presence of Heinz bodies
Inheritance of Glu-6-P dehydrogenase deficiency
x-linked recessive
