HMP Shunt (Pentose Phosphate Pathway)

Question 1

The HMP shunt occur in the cytosol of which tissues

Answer 1

cytosol of: Liver, adipose tissue, lactating mammary gland, adrenal cortex, testes, ovaries, erytrhocytes, leukocytes

Question 2

Which of the two phases of the HMP shunt is irreversible

Answer 2

oxidative phase (first phase)

Question 3

the coenzyme NADP is derived from which vitamin

Answer 3

vitamin B complex (niacin)

Question 4

What is the regulatory enzyme in the oxidative phase of the HMP shunt

Answer 4

Glucose-6-P. Dehydrogenase

Question 5

Which molecule is a negative regulator for Glucose-6-P. Dehydrogenase

Answer 5

NADPH

Question 6

Which molecule acts as an inducer of the gene to produce Glucose-6-P. Dehydrogenase

Answer 6

Insulin

Question 7

What are the enzymes needed in the non oxidative phase of the HMP shunt

Answer 7

isomerase, an epimerase , transketolase and transaldolase

Question 8

A low activity of which RBC enzyme can be an indication of thiamine deficiency

Answer 8

transketolase

Question 9

Which two molecules facilitate the integration between the HMP shunt and glycolysis

Answer 9

Fructose-6P and glyceraldehyde 3P

Question 10

NADPH from the HMP shunt is needed to maintain which molecule in its reduced state to be an antioxidant

Answer 10

glutathione

Question 11

glutathione is a requirement for which enzyme

Answer 11

glutathione peroxidase

Question 12

Which biosynthetic reactions are NADPH needed for

Answer 12

fatty acid and cholesterol biosynthesis

Question 13

Which vasodilator is NADPH needed for its synthesis

Answer 13

nitric oxide

Question 14

NADPH is need for hydroxylation of

Answer 14

cytochrome P-450

Question 15

NADPH in the presence of NADPH oxidase is needed during which process

Answer 15

phagocytosis

Question 16

NADPH oxidase deficiency is seen in which diseases

Answer 16

Chronic granulomatous disease (granulomas)

Question 17

Deficiency of NADPH makes phagocytic cells incapable of producing superoxide which results in a negative ______ test

Answer 17

NBT (nitroblue tetrazolium) test

Question 18

HMP shunt is needed for the production of _______ to make PRPP

Answer 18

Ribose-5-phosphate

Question 19

Deficiency in which enzyme causes decrease NADPH which leads to hemolysis

Answer 19

Glu-6-P dehydrogenase deficiency

Question 20

Person with Glu-6-P dehydrogenase deficiency are resistant to which deisease

Answer 20

malaria

Question 21

Malaria is caused by which parasite

Answer 21

plasmodium falciparum

Question 22

patients with Glu-6-P dehydrogenase deficiency are cautioned to avoid drugs that cause _____ stress

Answer 22

oxidative stress

Question 23

Glu-6-P dehydrogenase deficiency is a major cause of which kind of anemia

Answer 23

hemolytic anemia

Question 24

features of Glu-6-P dehydrogenase deficiency

Answer 24

Hemolytic anemia, hemolytic jaundice,

decreased level of reduced glutathione, presence of Heinz bodies

Question 25

Inheritance of Glu-6-P dehydrogenase deficiency

Answer 25

x-linked recessive