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Farmacología 1 parcial > hipolipemiantes > Flashcards

hipolipemiantes Flashcards

1
Q

estatinas mas potentes

A

atorvastatina y rosuvastatina

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2
Q

rabdomiolisis

A

estatinas y fibratos

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3
Q

no administrar estatinas con

A

gemfibrozilo (glucuronidacion) y ciclosporina A(el biliar)

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4
Q

hipercolesterelemia familiar homocigota

A

ezetimiba + estatinas

lomitapida

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5
Q

dislipemias

A

fenofibrato + estatinas

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6
Q

bloqueo NPC 1l1

A

ezetimiba

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7
Q

vit libosolubles tag o acidos grasos libres absorcion con ezetimiba

A

no afecta

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8
Q

de eleccion es sitoseloremia

A

ezetimiba

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9
Q

acido bempedoico inhibe

A

atp citrato liasa

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10
Q

alirocumab y evolocumab inhiben

A

proteina pcks9 internalizacion de rc LDL

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11
Q

tag y hdl alirocumab y evolocumab

A

aumentan tag y disminuyen hdl (contrario con ezetimiba y estatinas)

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12
Q

via admin alirocumab

A

sc

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13
Q

enfermedad cv aterosclerotica establecida

A

alirocumab evolocumab

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14
Q

sitostanol campostanol

A

esteroles vegetales que disminuyen absorcion de colesterol, en ID (no cambios en hdl y tag)

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15
Q

colestiramina colestipol colesevelam son

A

secuestradores de acidos biliares –> no modifican hdl y aumentan Tag?=

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16
Q

prurito asociado a colestasis

A

secuestradores de acidos biliares

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17
Q

acidos grasos poliinsaturados omega 3 funcion

A

dislipemias–> catabolismo FA (pueden aumentar LDL)

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18
Q

fibrato con accion uricosurica

A

fenofibrato

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19
Q

activan receptor ppar alfa

A

catabolismo de TAG y disminuye sintesis de apoproteinas (disminuye VLDL) fibratos

20
Q

mantienen igual LDL y aumentan HDL

A

fibratos

21
Q

acciones pleitropicas

A

fibratos y estatinas

22
Q

Gemofibrato rams

A

hipoglucemia grave

toxicidad estatinas

23
Q

disbetalipoproteinemia familiar

A

fibratos

24
Q

profarmaco

A

fenofibrato (baja BDO)

25
Q

lomitapida

A

inhbe proteina de transferencia TAG microsomal –> disminuye VLDL

26
Q

deficiencia LPL hereditaria

A

alipogen tiparvovec

27
Q

difsuncion erectil

A

inhibodes PDE5: sidenafilo (metabolito activo), vardenafilo, tadalafilo impide GMPc–> GMP

28
Q

CI sidenagilo

A

nitratos –> hipotension chunga

29
Q

HTA pulmonar prostaglandinas que aumentan AMPc via de admin (4)

A

epoprostenol -bomba de perfusion continua
treprostinil - sc o iv
iloprost - inhalatoria o iv
selexipag-oral

efecto rebote

30
Q

HTA pulmonar potencian via NO-GMPc (2)

A

inhibidores de PDE5- sildenafilo y tadalio (ii y III HTAP)

estimulantes GMPc- Rociguat (ii y III HTAP)

31
Q

htap tromboembolica

A

rociguat

32
Q

antagonizan efectos endotelina 1 HTAP

A

bosentan y macitentan ETA y ETB

ambrisentan ETA

33
Q

bosentan RAMs

A

aumenta transaminasas

daño hepatico

34
Q

ambristenan RAM

A

edema periferico

35
Q

fármacos para claudicacion intermitente

A 
iecas antiescleroticos antiagregantes
pentoxifilina
naftidrofurilo
cilostazol
iloprost
36
Q

Pentoxifilina

A

VD y hemorreologico

inhibe PDE y aumenta AMPc

37
Q

antagonista 5ht2 (antiagregante plaquetario y VD)

A

naftidrofurilo- tb sdo de raynaud

38
Q

cilostazol

A

inhibidor PDE3A aumenta ampc (no en cronico y ci en IC)

39
Q

mayor riesgo de amputacion usar

A

iloprost

40
Q

minoxidil y diazoxido

A

canales K atp (crisis hipertensivas)

41
Q

util en diabetes

A

diazoxido

42
Q

alopecia

A

minoxidil

43
Q

VD arterial

A

hidralazina –> sdo como lupus en tto cronico, agudo HTA en embarazo

44
Q

nitrato sintetico o inorganico

A

nitroprusiato sodico (vd arterial y venoso)–>uci en crisis hipertensivas e hipotension en qx

45
Q

tto cronico nitroprusiato sodico

A

tiocianato –> tirotoxico

Farmacología 1 parcial (15 decks)

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