Hepatitis 1

Question 1

how long does acute viral hepatitis last?

Answer 1

weeks to months

Question 2

how long does chronic viral hepatitis last?

Answer 2

years to lifetime

Question 3

what is fulminant disease hepatitis?

Answer 3

sudden severe acute liver failure

Question 4

features of viral hepatitis?

Answer 4

jaundice, dark urine, pale faeces, flu-like

Question 5

does virus cause hepatocyte damage?

Answer 5

nope, usually immune response

Question 6

can hepiatitis cause cancer?

Answer 6

yes

Question 7

what is cirrhosis?

Answer 7

scarring from chronic liver damage

Question 8

Which hepatitises are infectious?

Answer 8

A and E

Question 9

Which hepatitises are ‘serum’?

Answer 9

B,D and C

Question 10

are hepatitis viruses cytolytic?

Answer 10

no

Question 11

what happens if you are exposed to hep early in life? 2 things

Answer 11

less severe acute disease

higher rates of chronic infection

Question 12

are hepatitis viruses related to each other? do you get cross protection?

Answer 12

no

no cross protection

Question 13

Which hepiatitises are acute?

Answer 13

A and E

Question 14

Which hepiatitises are chronic?

Answer 14

B,C,D

Question 15

where does Hep A replicate first?

Answer 15

in intestinal epithelia

Question 16

can Hep A survive stomach?

Answer 16

yes

Question 17

Hep A is enveloped? dsRNA? + or -

Answer 17

non-enveloped (+)ssRNA virus

Question 18

where does Hep A replicate second?

Answer 18

liver

Question 19

How does Hep A transmit mainly?

Answer 19

food/water contamination

Question 20

How is HBV and HCV mainly transmitted?

Answer 20

IV drug/sexual

Question 21

increased ALT liver enzyme indicates what?

Answer 21

presence or replicating virus

Question 22

acute infection Hepatitis levels for IgG and IgM?

Answer 22

high for IgM

low for IgG

Question 23

chronic infection Hepatitis levels for IgG and IgM?

Answer 23

low for IgM

high for IgG

Question 24

Hep A IgM ELISA is good or bad for dx?

Answer 24

good
sensitivity >90%
Specificity >99%

Question 25

are nucleic acid tests for hep A better or worse for ELISA?

Answer 25

inferior to ELISA

Question 26

Hep A incubation period?

Answer 26

15-50 days

average 30 days

Question 27

do kids <6 get symptoms for Hep A?

Answer 27

<10%

Question 28

how long do hep A symptoms last?

Answer 28

2-3 weeks

Question 29

how long do you have to give HAV post-exposure immune globulin?

Answer 29

14 days

Question 30

treatment for Hep A?

Answer 30

supportive rehydration and nutrition

Question 31

Hep A virus vaccine is cheap or expensive?

Answer 31

expensive

Question 32

Hep A virus vaccine how created?

Answer 32

grown in culture
inactivated whole firus with formalin
>95% effective after 1 dose

Question 33

Hep E is enveloped? tough? fragile?

Answer 33

non enveloped/fragile

Question 34

what is Caliciviridae?

Answer 34

Hep E

Question 35

Hep E outbreaks usually cause of?

Answer 35

contaminated water

Question 36

person-to-peron transmission in Hep E?

Answer 36

minimal

Question 37

Hep E incubation?

Answer 37

2-10 weeks

40 days average

Question 38

Hep E fatalities?

Answer 38

low overall

preg: 15-25%

Question 39

Hep E vaccine?

Answer 39

nope.

Question 40

100% of adult Hep E get?

Answer 40

jaundice

Question 41

what is a feature in 50% of Hep E cases?

Answer 41

cholestasis

Question 42

Hep E affects which cells? 3 things

Answer 42

intestinal muscosa
Kupffer cells
Hepatocytes

Question 43

Hep E secreted?

Answer 43

in faeces

Question 44

Hep E diagnosis best way? for who usually?

Answer 44

ELISA assay for travelers and outbreaks

Question 45

can you use immune serum globulin for Hep E?

Answer 45

NOPE.

Question 46

treatment for Hep E?

Answer 46

supportive therapy