hepatic Flashcards
GGT (gamma glutamyl transferase), ALP, and TBIL → tell us about
bile ductal cells
ast and alt detect
injury to hepatocytes
Best test for measuring day to day synthetic function of the liver:
prothrombin time/INR
ercp?
allows you to treat and dx probs of the liver, GB, bile ducts, and pancreas
ercp procedure
Endoscope goes into the duodenum, dye is injected into CBD, and can see by fluoroscopy
portal htn back up
Blood backs up in the stomach, intestines, spleen, pancreas, when portal venous system is backed up
portal htn leads to
esophageal varices and hemorrhoids
cirrhosis?
Fibrosis and nodules in liver
dx ascites
Dx with US or CT… hard to dx on PE
ascites trmt
Trmt- Na restriction, diuretics
Kayser fleischer rings
corneal copper deposition in wilson’s disease
Fetor hepaticus?
(bad odor of breath and urine)
guaiac + stools are a sx in this disease
cirrhosis
Asterixis ?
flappy tremor of arms
choreoathetosis ?
dancing extremities
common causes of cirrhosis
Common: Hep B and C, alcoholic liver disease, hemochromatosis, NASH (nonalcoholic steatohepatitis)
Extrahepatic cholestasis?
Bile flow from liver is reduced bc of an obstruction outside the liver
Intrahepatic cholestasis?
Bile flow from liver is reduced bc of an obstruction inside the liver
Primary sclerosing cholangitis (PSC)?
Chronic progressive inflammation, fibrosis, and stricturing of medium and large ducts in intra and extra hepatic biliary tree that leads to fatigue
Primary sclerosing cholangitis (PSC)
cause
unknown
Primary sclerosing cholangitis (PSC) sx
Asymptomatic
Fatigue, pruritus (from hyperbilirubinemia), RUQ pain, arthropathy
Primary sclerosing cholangitis (PSC)
pe
May be normal
Hypopigmentation, excoriation (from itching), jaundice
Late stage: ascites, clubbing, edema
Primary sclerosing cholangitis (PSC)
dx
\+ antimitochondrial antibodies (AMA) Inc LFT esp. Alk phos Histology shows Asymmetric destruction of bile ducts Do liver biopsy, MRCP, ERCP Need all 3 to dx
Associated with UC
Primary sclerosing cholangitis (PSC)
“Beading of bile ducts”
Primary sclerosing cholangitis (PSC)
Primary sclerosing cholangitis (PSC)
2 trmt goals
Slow and reverse disease progression- many drugs dont succeed
Manage disease and complications
Primary sclerosing cholangitis (PSC)
trmt
Ursodeoxycholic acid (UDCA)/Ursodiol is best
Endoscopic therapy to dilate or stent the stricture
No widely acceptable trmt
Treat underlying sx: itching, bone disease, hyperlipidemia
Ursodeoxycholic acid (UDCA)/Ursodiol- good if trmt starts early bc it thins the bile duct
Cholestyrene resin reduces pruritis
Liver transplant if they think you’ll die within a year
Acute Hepatitis A
cause
Hep A virus (HAV)
Acute Hepatitis A
sx
Nausea, vomiting, fatigue, diarrhea, fever, jaundice
Acute Hepatitis A
prevention?
yes, Vaccine
Acute Hepatitis A
transmission
Fecal oral route
No bloodborne transmission
Hepatitis B
cause
Hepatitis B virus (HBV)- DNA virus
Hepatitis B
transmission
Transmitted by blood, sex
Present in saliva, semen, or vaginal secretions
HBsAg + mothers can transmit HBV when delivering baby
Hepatitis B
sx
Anorexia, NV, malaise
Fever, enlarged liver and tender, jaundice