HEMOSTASIS DISEASES Flashcards
what are the vitamin K dependent factors?
2, 7,9 10, and protein C
what are the three particular types of bleeding tendencies?
Vitamin K Deficiency, Hemophilia, Thrombocytopenia (platelet deficiency)
an infection and inflammation in the liver
hepatitis
there is a scarring in your liver
cirrhosis
Decreased formation of Vitamin K dependent factors
vitamin K
decrease of vitamin K causes?
excessive bleeding
where is vitamin K continually synthesized?
in the intestinal tract by bacteria
a disease where vitamin K deficiency occurs
as a result of poor absorption of fats from the GIT
GI disease
One of the most prevalent causes of Vitamin K deficiency-
failure of the liver to secrete bile
is injected into surgical patients with liver disease or with obstructed bile ducts
Vitamin K
is the presence of stones in the common bile duct or biliary tree
Choledocholithiasis
Bleeding disease that occurs almost exclusively in males
Hemophilia
a disease where 85% abnormality or deficiency of Factor VIII
Hemophilia A or classic hemophilia
a disease where 15% deficiency of Factor IX
Hemophilia B
what are the 2 active components of factor VIII?
Large component and smaller componenet
what does the large component in factor VIII cause?
Von Willebran Disease
one of the two components of factor VIII where it is the deficiency cause hemophilia
Smaller component
Presence of very low number of platelets
Thrombocytopenia
The patient has a tendency to bleed usually from many
small venules or capillaries that’s why you have small punctate hemorrhages or small purplish blotches, or we call that ________
purpura
n the case of patient presenting dark purplish blotches or there is purpura ,so we call that _______
Thrombocytopenic purpura
hemophilia occurs in ______ vessels while thrombocytopenia occurs in _________ vessels.
Large, small
what do you call where purpura a larger in cases?
ecchymosis
it is the bleed of usually from many small venules or capillaries
small punctuate hemorrages
Bleeding will not occur until the number of platelets falls ____________ u/L
below 50,000
specific Ab have formed and
react against platelets to destroy them.
Idiopathic thrombocytopenic
abnormal clot that develops in a blood vessel; immobile
Thrombus
clot that breaks away from its attachment cause the clot to
flow with the blood; mobile
Emboli
what are the causes of Thromboembolic conditions?
Roughened endothelial surface of a vessel and when it flows slowly
Immobility of patients confined to bed plus the practice of propping the knees with pillows
Femoral Venous Thrombosis
Patients confined to bed such as those in the ICU or bed-
ridden patients have the tendency to form ________
intravascular clotting
heart going to the lungs that would now cause blockage this refers to the condition
‘Pulmonary embolism’
other term of consumptive coagulopathy
disseminated intravascular dissemination
Consumption of procoagulants = _____________
consumptive coagulopathy
what is the quantity of heparin injected in the body?
0.5-1 mg/kg
how many hours does the heparin last?
1.5-4hours
what are the active component that fall during warfarin?
active prothrombin, Factor VII, IX, and X
what are the chemicals used in the prevention of blood coagulation outside the body
heparin, oxalate and citrat
a prevention of blood coagulation where it is used in surgical procedures in which the blood must be
passed through a heart-lung machine or artificial kidney machine
heparin
a prevention of blood coagulation where precipitation of calcium oxalate from the plasma and
thereby decreases the ionic calcium level
oxalate
what is the color of the top of the tube with oxalate?
Gray top tube
Prevent the initiation of the coagulation system
oxalate
one of the chemicals for the prevention of blood coagulation where it Prevent the initiation of the coagulation system
oxalate
lack of clotting factors prolongs?
bleeding time
a method where you puncture the drop of blood should be
placed in the filter paper and it will be timed. So, the Normal value is 1-6 minutes.
IVY METHOD
normal time value of clotting in IVY method?
1-6 minutes
what do you call the time required for coagulation to take place?
prothrombin time
what is the normal prothrombin time?
12 secs
puncture the drop of blood should be
placed in the filter paper and it will be timed. So, the Normal value is 1-6 minutes.
IVY METHOD
INR meaning?
international Normalized Ratio
what is the normal INR range?, Risk of high bleeding? clotting ratio of INR? of the parathrombin
0.9-1.3 , 4-5 , 0.5
ndicates the activity of the tissue factor with a standardized sample
internal sensitivity index
the internal sensitivity index varies between ?
1-2
normal value of clotting time?
6-10 minutes
