Heme 1 Flashcards
most common type of hemophilia in the US
hemophilia A
hemophilia A
x linked recessive disease that predominantly affects males who have only one x chromosome - caused by factor VIII deficiency
s/sx of hemophilia A
6
easy bruising
excessive bruising
bleeding into joints (hemarthrosis)
delayed bleeding or bleeding for several hours to days
heavy menses
hematuria
hemophilia A labs - aPTT, PT, fibrinogen, plts
aPTT is prolonged
normal - PT, fibrinogen, plts
hodgkin’s lymphoma
cancer of the beta lymphocytes (B cells)
cancer of the beta lymphocytes (B cells)
hodgkin’s lymphoma
hodgkin’s lymphoma s/sx
6
night sweats
fevers
pain w/ alocholic drinks
pruritis
painless enlarged lymph nodes (neck)
anorexia
hodgkin’s lymphoma is identified by the presence of what cells
Reed-Sternberg cells
multiple myeloma
cancer of the plasma cells
cancer of the plasma cells
multiple myeloma
multiple myeloma s/sx
6
fatigue
weakness
bone pain usually in back or chest
proteinuria
hypercalcemia
normocytic anemia
common meds that can cause neutropenia
7
psychotropics
antivirals
abx
NSAIDs
antithyroids
ACEIs
propanolol
non-hodgkin’s lymphoma
a group of metalogic malignancies that are derived from B cell progenitors, T cells progenitors, mature B cells, mature T cells, or natural killer cells
usually occurs in older adults >65, presents with night sweats, fever, weight loss, and painless lymphadenopathy
non-hodgkin’s lymphoma
gradual onset of symmetric peripheral neuropathy starting in the feet and/or arms
vitamin b12 deficiency
vitamin b12 def - cells are micro or macro
macro
the proportion of RBCs in 1 mL of plasma
hct
micro value
<80
macro value
> 100
average hgb content in a RBC
MCH
the stored form of iron
serum ferritin
most sensitive test for IDA
serum ferritin
serum ferritin level - IDA
decreased
serum ferritin level - thalasemmia
normal to high
serum iron level - IDA
decreased
serum iron level - thalassemia and macrocytic anemias
normal to high
immature RBCs that still have their nuclei
reticulocytes
gold standard test to dx hemoglobinopathies such as SCA, thalassemia, and more
hgb electrophoresis
order what two labs when evaluating MCV >100
B12 and folate levels
microcytic, hypochromic anemias
2
IDA
thalassemia
B12 and folate def anemia size and color
macro, normo
anemia of chronic disease MCV and MCH
normalcytice, normochromic
SCA RBC normal life span
10-20 days
SCA MCV and MCH
normocytic/normochromic
