Healthy Animals Block 1 Flashcards
What are the 2 types of glands?
Exocrine and endocrine
What is an endocrine gland?
Secrete products in extra cellular space where it is taken up into the blood vascular system
What is an exocrine gland?
Secrete products into a gland where they are taken to the free surface, either the lumen of an organ or the onto the free surface of the epithelium.
What is a merocrine gland?
Uses secretory vesicles to the lumpen of the gland
What is a holocrine gland?
Death of entire cell and product sloughs off into the lumen of the gland
What is an apocrine gland?
Release of budding vesicles (parts of the cell)
What are gap junctions
They connect the cytoplasm of two cells
Where do hemidesmosomes attach
To the basement membrane
Where do desmosomes attach?
To bordering cells (not basement)
What are the 3 components of connective tissue extracellular matrix
Protein fibers, glycoproteins, proteoglycans
What are the 3 types of extracellular fibers?
Collagenous fibers, elastic fibers, reticular fibers
What are the 2 non-cellular biological materials that make the connective tissue
Fiber component and ground substance
What is a large chain of collagen molecules called?
Fibril -> fibers
What are the 5 types of collagen
1-5
What is type 1 collagen?
Found in every connective tissue
What is type 2 collagen
Found in hyaline and elastic cartilage and in vitreous of eye
What is type 3 collagen
Found in reticular fibers, healing wounds, smooth muscle, and fetal skin
What is type 4 collagen
Found in basal laminae of epithelia
What is type 5 collagen
Found in placental basal laminae, tendons, and muscle sheath
What is ground substance?
Aqueous gel of glycoproteins and proteoglycans
What do fibroblasts secrete
Both collagen and ground substance
What is are 2 examples of specialized connective tissue?
White and brown adipose
What are the 4 types of connective tissue
Dense irregular, loose irregular, dense regular, and embryonic connective tissue
What are the holes that chondrocytes are found in called?
Lacunae
What are the 3 types of cartilage?
Hyaline cartilage, elastic cartilage, fibrocartilage
Where is fibrocartilage found and what type of collagen makes it up
Type 1 collagen and found at attachment points for tendons, intervertebral discs, and symphysis between bones
Where is elastic cartilage found and what collage makes it up
Type 2 and the pin a of the ear, the turbinates of the nose, and the epiglottis
Where is hyaline cartilage found and what collagen type makes it up
Type 1 and articular surface in joints
What are the two types of epithelium genres
Lining epithelium and glandular epithelium
What type of gland is a sebaceous sweat gland?
Holocrine
What type of gland is an apocrine sweat gland?
Apocrine
What is the outer membrane of most organs called?
And what is it made of?
Serosa made of mesothelium
What is the term for keratinized cells?
Cornification
What is the function of reticulin in cartilage?
Acts as a net to hold cells of an organ together
What is the only type of connective tissue without vascularation
Cartilage
What can smooth and cardiac muscle react to that skeletal muscle cannot?
Catecholamines (epinephrine and norepinephrine)
What is myoepithelium
A specialized type of epithelium located around glands that can contract and move it onto the surface
What is myofibroblasts?
Seen in healing wounds and assists in maturation and contraction of granulation tissue
What muscle type causes shivering?
Skeletal
What is a synonym to muscle cell?
Muscle fiber
What are the 3 layers of connective tissue that encloses muscles from highest to lowest order?
What type of connective tissue is it?
Epimysium, perimysium, endomysium
Dense irregular connective tissue
Where are the nuclei located on skeletal muscles? How many nuclei are in a skeletal muscle?
In the periphery
Many
What is the individual muscle bundle within the perimysium called?
The fascicle
What is the cytoplasm of a muscle cell called?
Sarcoplasm
What is the plasma membrane of a muscle cell called?
Sarcolemma
What is the smooth ER that controls the release of calcium called?
Sarcoplasmic reticulum (SR)
What is the functional unit of skeletal muscle called?
Sarcomere
What is a chain of sarcomeres called?
A myofibril
Where, specifically, is cardiac muscle found?
In the myocardium
Where is the nucleus of cardiac muscle and how many nuclei does it have?
Middle and singular (usually)
What is the purpose of intercalated discs
Alls contraction of cardiac muscle in a coordinated manor through gap junctions and desmosomes.
How can you tell the difference between smooth muscle and connective tissue?
The nuclei of smooth muscle is longer than in fibroblasts
What is the organic component (type 1 collagen + ground substance) called
Osteoid
What is the inorganic matrix of bone?
Calcium hydroxyapatite
What is all normal bone in adults called?
Lamellar bone
What is the difference between osteoblasts and osteocytes
Osteoblasts produce bone and line the edge of growing bone while osteocytes are embedded in lacunae within the bone matrix
What are the long cytoplasmic processes of osteocytes called?
Canaliculi
What are the roles of osteocytes?
They play and important role in detecting local changes in the micro environment looking for stress, micro fractures, and micronutrient concentrations.
What is the outside portion of bone called?
Cortical bone
What is the inside portion of bone called?
Trabecular bone
What recruits an osteoclast to the bone?
Osteoblasts recruit osteoclasts
What do osteoclasts secrete to break down bone?
Carbonic acid and proteinases
What is the scalloped region created by the osteoclast called?
Howship’s lacuna
What is the bone type of immature animals
Woven bone
What is an osteon (long answer)
A Haversian canal (center of osteon) is an osteon which is a structure that has a cutting cone where osteoclasts line the front, continuously cutting away while osteoblasts line the bottom of the cone, constantly rebuilding with a blood vessel running up the middle, aka the Haversian canal. Cool!!
What is the term for changes in bone size and shape?
Modeling, how bone responds to loading
What is Wolff’s Law?
Bone shape will adapt to use
What is the process of removing bone in one place and replacing it in another?
Remodeling
What are the 2 ways that bone can grow?
Membranous ossification and endochondralmossification
Where does membranous ossification usually occur?
Flat bones like skull and mandible
Where does endochondral ossification usually occur?
Long bones
What is the growing plate of a long bone called?
The physis
What are the 4 zones of endochondral ossification from most chondral to bone
Zone of reserve cartilage, Zone of proliferation, zone of hypertrophy, zone of calcification
Where is the only region to find chondroblasts?
Perichondrium (surrounding tissue of hyaline, only present during period of growth or injury)
Since hyaline cartilage is avascular, what nourishes the cells?
Synovial fluid
What are the fibers of tendons that anchor into bone called?
Sharpey’s fibers
What are the specialized cardiac cells that lack T tubules and aid in conduction system?
Purkinje fibers
What triggers the release of neurotransmitters in a neuron?
Depolarization
What units is the resting potential measured in?
Millivolts (mV)
What is the resting potential?
-90mV (negative charge on the inside of the membrane)
What cellular mechanism is responsible for creating the membrane potential and how many of each is pumped? And what does it require?
ATP dependent Na K pumps pumps 3 Na out and 2K into the cell which actually creates a -4mV potential because 1 more positive molecule is moved outside than inside
After the ATP dependent sodium potassium channel, what is the next step in polarization?
A potassium leak channel allows only potassium to diffuse down its concentration gradient to allow the buildup of - proteins on the membrane to build up
What initiates the action potential?
The voltage gated sodium channel opens allowing sodium to flood into the neuron and depolarize the cell.
Although the brain makes up 2% of body weight, it uses how much energy
15%
Describe the steps of repolarization
Voltage gated sodium channel is closed, voltage gated potassium channel is opened, Na/K pump is restarted
How do neurons get ATP energy?
They use aerobic (needs lots of oxygen) glycolysis because it yields the most energy
What and how stabilizes the outside gate of the voltage gated sodium channel
Ca++ stabilizes the outside gate between -90 and -50. Decreases in 50% of calcium can cause wrongful firing of the neurons
What initiates the fusion of neurotransmitter ventricles to the membrane?
Depolarization activates voltage gated calcium channels and the influx causes neurotransmitters to bind to the membrane
What are the 2 general types of neuro receptors on the post synaptic membrane? And their speed of action?
Ion channel (quick and fast)
Enzyme receptors (long and slow) up to years
What are the 2 possible outcomes of receptor binding to the post synaptic cleft? And what are their actions?
Inhibitory (opening of potassium channels) or excitatory (opening of sodium channels)
What is excitotoxicity?
When there is an excessive release of excitatory neurotransmitters from an injured or degenerating nerve (like releasing excessive glutamate which will cause binding to a receptor)
What are dilated segments of an axon called?
Spheroids
What happens when an axon or neuron dies in the CNS?
It’s gone… no regeneration
What happens when an axon or neuron dies in the PNS?
Schwann cells help to regenerate it
What are glial cells
Glial cells are supporting non-neuronal cells of the neural system
What is the insulation made by glial cells and what is it made of?
Lipid and myelin
What are the exposed patches of axon through myelin?
Nodes of Ranvier
What is the process of jumping charges from node of ranvier called?
Saltatory conduction
What are the 2 benefits to myelination?
Faster and requires less energy
What are the glial cells called in the CNS?
Oligodendrocytes, forms with multiple other axons
What are glial cells of the PNS?
Schwann cells (one cell per myelon)
What is a neurilemmal tract?
A neurilemmal tract is basement membrane and collage that are on Schwann cells opposite of the axon that allows for regrowth of the PNS
What is primary and secondary demyelination and how can you tell the difference
Primary is simply loss of that myelin cell by damage. Secondary is the loss of tropic factors due to the neuron dying. It is primary demyelination if the neuron/axon is still there, if it isn’t then it is secondary
What are causes of primary demyelination?
Viral infection, immune mediated, metabolic damage, and toxins (rat poisoning)
Which type of myelin is easier to replace?
Schwann since one cell is responsible for one axon part while oligodendricites are responsible for 20-50 axons