HEALING PATHWAY Flashcards
steps of the healing pathway?
injury hemostasis inflammation induction/recruitment proliferation remodeling stabilization/maturation
importance of hemostasis?
activation of intrinsic coagulation cascade
platelet aggregation
fibrin deposition/platelet plug
importance of inflammation?
cytokine released by activated platelets
increased vascular permeability
migration of inflammatory cells like macrophages
major roles of macrophages?
phagocytosis wound debridement cell recruitment angiogenesis matrix synthesis regulation
importance of proliferation?
fibroblast replication
synthesis of ECM
recruitment of native cells
importance of remodeling?
primarily controlled by fibroblasts
lasts from 3 weeks to many years
major role of fibroblast?
synthesize and deposit the ECM
most important collagen types?
what is initially laid to become what type?
what type is cartilage, what is significant?
I,II,III
III to I
II, hard to heal
what are the local factors affecting tissue healing?
infection perfusion edema pressure/friction dessication
what are the systemic factors affecting tissue healing?
age
nutritional status
disease states like diabetes
medications/drugs, corticosteroids
chronic complication of diabetes?
blindness kidney disease nerve damage amputation cardiovascular disease stroke heart attack loss of circulation in arms and legs
normal acute blood sugar level?
185 mg/dl
