Haematology Drugs and Tests Flashcards
What is Prothrombin Time Measuring/ PT?
Extrinsic Pathway
Factors:
VII, X, V, II and fibrogen
What does APTT measure?
Intrinsic Pathway
XII, IX, XI, X, VIII, II and fibrinogen
What does the clotting time measure?
how long it takes for fibrinogen to turn to fibrin.
the tests literally add thrombin. therefore it is not relying on any of the factors other than fibrinogen.
indication of:
- decreased fibrinogen
- inhibitor
How does Warfarin work?
Blocks Vitamin K Oxide Reductase
No Reduced Vit K made.
No Carboxy-glutamic Acid Residues made on factors. therefore Ca2+ can’t bind and activate.
What factors for Warfarin disabled?
II, VII, IX, X
Protein C
Protein S
Name a factor IIa inhibitor:
Dabigatran
Name three factor Xa inhibitors:
Rivaoxaban
Apixaban
Edoxaban
Name a reversal drug of dabigatran:
Idarucizumab
Name two kinase fibrinolysis:
Streptokinase
Urokinase
Name three tissue plasminogen activators:
Atelplase
Tenecteplase
Reteplase
Name two ADP inhibitors:
Clopidogrel
Ticlopidine
By blocking ADP receptors on platelets, what is achieved?
decreased expression of:
Glycoproteins IIb/ IIIa
reduced fibrinogen binding
Name two GP IIb/ IIIa antagonists:
Abciximab
Tirofiban
Name phosphodiesterase III inhibitor and how does it work?
Dipyridamole
Blocks cAMP levels from being reduced. thus maintaining them.
which deactivates platelets.
What are the common pathway factors, and what would the result be on the APPT and PT?
1,2,5, and 10
both would be increased as both involve them
