G.I infections Flashcards

1
Q

What are the 6 major groups of E. Coli that cause G.I infection:

A

Enteropathogenic

Enterotoxigenic

Enterohaemorrhagic

Entero- invassive

Entero-aggregative

Diffuse Aggregative

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2
Q

What is most typically associated with traveler’s diarrhoea?

if it requires treatment, how is it treated?

A

Enterotoxigenic E. Coli

Heat Liable toxin
+/-
Heat Stable toxin

Ciprofloxacin

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3
Q

What infection is caused by E.Coli 0157

A

Enterohaemorrhagic

Shigella like toxin

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4
Q

How does Campylobacter jejuni cause infection?

A

Invassion into the G.I epithelium

Bloody diarrhoea

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5
Q

What are some complications of salmonella enterica infection?

A

Osteomyelitis

Septic Athritis

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6
Q

What bacteria causes dysentery?

A

Shigella Dysenteriae

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7
Q

What types of serology are found on vibrio cholerae?

A

Serology 01

Serology 0139

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8
Q

What is the incubation period of Staph Aureus infection of the G.I?

A

Short 30mins - 6 hours

perfuse vomiting

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9
Q

What bacteria is usually associated with fried rice, cooled rice and produces heat stable spores?

A

Bacillus Cereus:

Emetic disease.

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10
Q

What bacteria is often associated with bulk cooking, usually meat products, which have allow spores to germinate?

A

Clostridium Perfringens

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11
Q

What severity markers are used to assess C. Diff?

A

Colonic dilation > 6cm

WCC > 15

Creatinine 1.5 x baseline

Temperture > 38

Immunosuppresion

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12
Q

What bacteria is implicated in pregnant women and is often found in soft cheeses, coleslaw, unpasteurised milk?

A

Listeria monocytogenes

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13
Q

How does listeria monocytogenes usually present?

A

Initially flu like symptoms:

2 weeks later:
Septicaemia
Meningitis

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14
Q

Which bacteria can survive very cold temperatures, such as seen in the fridge?

A

Listeria m`onocytogenes

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15
Q

What are the two toxins produced by S. Aureus?

A

enterotoxins type A & E

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16
Q

Where are most the chlorea epidemics?

A

Africa

Asia

South america

17
Q

What lab techniques can be used to try and identify bacteria?

A

Enrichment broth
- to grow particularly bacteria

Selective media
- suppressing background flora

Differential media

  • MacConkey’s media
  • lactose fermenting
18
Q

What is the class of virus that the norovirus belongs too?

A

Calciviridae family

19
Q

What kind of virus is the norovirus?

A

positive sense, single stranded RNA

20
Q

What is the most common genotype of the norovirus?

A

GII - 4

21
Q

What kinda of virus is the rotavirus?

A

Double stranded RNA

22
Q

What are the main strains of rotavirus?

A
G1
G2
G3
G4
G9
23
Q

Whats the vaccine against rotavirus?

A

Rotarix

24
Q

What causes enteric fever?

A

Salmonella Typhi

Salmonella Paratyphi

25
Q

What are some complications of enteric fever?

A

Bowel perforation - Peyer patches hyperplasia

Enteric Encephalopathy
- dissemination of bacteria throughout

Septic shock

26
Q

How do you treat enteric fever?

A

Cephalosporins
- empirical therapy

Quinolones

27
Q

How does vibro cholera cause diarrhoea?

A

Hydrolyses the mucus membrane

28
Q

What receptors mediate E. Coli binding to the gut?

A

Intimin

Translocated itimin receptor

29
Q

What kinda of virus is the Adenovirus and what are the main sub types?

A

doubel stranded DNA

40
41

30
Q

How long is C.Diff treated for?

A

Metradindazole 10 days

31
Q

What is the treatment of C. Diff if there is any complications i.e. colonic dilation?

A

Vancomycin

32
Q

What antibiotics are most commonly associated with C.Diff infection?

A

Ciprofloxacin (all quinilones)

Co-amoxiclav

Clindamycin

Cephalosporins

33
Q

How is syphilis diagnosed and how is it treated?

A

Dark field microscopy of chanres

Serology of blood.

Penicillin - via injection

34
Q

How is chlamydia diagnosed and how is it treated?

A

NAAT from swabs

Doxycycline or azithromycin

Should also treat for Gonorrhea as infections usually co-exist
- ceftriaxone

35
Q

How is N. Gonorrhea treated?

A

Ceftriaxone
+
Azithromycin

36
Q

What bacteria that cause G.I infection are effected by acid? and what drugs can increase the risk of infection from them?

A

Salmonella

Omeprazole

37
Q

Whats the most common infection of shigella?

and what is the most severe infection of shigella?

A

Shigella Sonnei

Shigella Dysenteriae