Glomerulonephritis 2 Flashcards
Commonest cause of nephrotic syndrome in children
Minimal change nephropathy
Treatment for minimal change nephropathy
1st line: steroids
2nd line: cyclophosphamide
Will minimal change lead to progressive renal failure?
No
Commonest cause of nephrotic syndrome in adults
FSGS
focal segmental glomerulosclerosis
Follow HIV/heroin use/obesity/reflux nephropathy
FSGS
focal segmental glomerulosclerosis
Will FSGS progress to end stage renal failure?
Yes, 50% will have within ten years
Treatment for FSGS
Steroids
Important causes of membranous nephropathy?
Infections (hep B/parasites)
CTDs (lupus)
Malignancies (carcinoma/lymphoma)
Drugs (gol, penicillamine)
Drugs which could cause membranous nephropathy?
Gold, penicillamine
Infections which could cause membranous nephropathy?
Hep B, Parasites
CTDs which could cause membranous nephropathy?
Lupus
Malignancies which could cause membranous nephropathy?
Carcinoma, lymphoma
Type of GN that follows HepB
Membranous
Type of GN associated with CTDs
Membranous
Type of GN that occurs in gold/penicillamine use
Membranous
Could you progress to end stage renal failure following membranous nephropathy?
Yes, 30% progress
Treatment for membranous nephropathy
Steroids/alkylating agents/B cell monoclonal antibody
Nephropathy that follows resp/GI infection
IgA nephropathy
Nephropathy associated with AKI/CKD
IgA nephropathy
Nephropathy associated with HSP
IgA nephropathy
Mesangial cell proliferation and expansion on light microscopy with IgA deposits in mesangium on IF
IgA nephropathy
Subepithelial imune complex deposition in the basement membrane
Membranous nephropathy
Does IgA nephropathy progress to ESRF?
Yeah, 25%
Management of IgA nephropathy?
BP control/ACEi/ Fish oil
