Glomerulonephritis 2 Flashcards

1
Q

Commonest cause of nephrotic syndrome in children

A

Minimal change nephropathy

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2
Q

Treatment for minimal change nephropathy

A

1st line: steroids

2nd line: cyclophosphamide

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3
Q

Will minimal change lead to progressive renal failure?

A

No

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4
Q

Commonest cause of nephrotic syndrome in adults

A

FSGS

focal segmental glomerulosclerosis

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5
Q

Follow HIV/heroin use/obesity/reflux nephropathy

A

FSGS

focal segmental glomerulosclerosis

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6
Q

Will FSGS progress to end stage renal failure?

A

Yes, 50% will have within ten years

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7
Q

Treatment for FSGS

A

Steroids

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8
Q

Important causes of membranous nephropathy?

A

Infections (hep B/parasites)
CTDs (lupus)
Malignancies (carcinoma/lymphoma)
Drugs (gol, penicillamine)

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9
Q

Drugs which could cause membranous nephropathy?

A

Gold, penicillamine

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10
Q

Infections which could cause membranous nephropathy?

A

Hep B, Parasites

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11
Q

CTDs which could cause membranous nephropathy?

A

Lupus

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12
Q

Malignancies which could cause membranous nephropathy?

A

Carcinoma, lymphoma

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13
Q

Type of GN that follows HepB

A

Membranous

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14
Q

Type of GN associated with CTDs

A

Membranous

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15
Q

Type of GN that occurs in gold/penicillamine use

A

Membranous

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16
Q

Could you progress to end stage renal failure following membranous nephropathy?

A

Yes, 30% progress

17
Q

Treatment for membranous nephropathy

A

Steroids/alkylating agents/B cell monoclonal antibody

18
Q

Nephropathy that follows resp/GI infection

A

IgA nephropathy

19
Q

Nephropathy associated with AKI/CKD

A

IgA nephropathy

20
Q

Nephropathy associated with HSP

A

IgA nephropathy

21
Q

Mesangial cell proliferation and expansion on light microscopy with IgA deposits in mesangium on IF

A

IgA nephropathy

22
Q

Subepithelial imune complex deposition in the basement membrane

A

Membranous nephropathy

23
Q

Does IgA nephropathy progress to ESRF?

A

Yeah, 25%

24
Q

Management of IgA nephropathy?

A

BP control/ACEi/ Fish oil

25
Q

RPGN associated with _____ on biopsy

A

Glomerular crescents

26
Q

Type of nephropathy associated with vasculitis?

A

RPGN

27
Q

Treatment for RPGN

A

Immunosuppression
Steroids (IV Methylprednisolone / Oral Prednisolone)
Cytotoxics (Cyclophosphamide/ Mycophenolate/ Azathioprine

Plasma phoresis