AKI Flashcards
What is an abrupt (<48hrs) reduction in kidney function defined as?
an absolute increase in serum creatinine by >26.4µmol/l
OR increase in creatinine by >50%
OR a reduction in UO (urine output)
Can only be applied following adequate fluid resuscitation & exclusion of obstruction
Increase >26µmol/L or
Increase > 1.5-1.9 x reference Cr
< 0.5 mL/kg/hr for > 6 consecutive hrs
KDIGO stage 1
Increase > 2 to 2.9 x reference SCr
< 0.5mL/kg/hr for > 12 hrs
KDIGO stage 2
Increase > 3 x reference SCr or increase to > 354
µmol/L or need for RRT
24hrs or 12 hrs for anuria
KDIGO stage 3
Drugs which could cause renal hypoperfusion?
NSAIDs/COX-2
ACEi/ARBs
Hepatorenal syndrome
Normal urine output?
0.5ml/kg/hour
What is oliguria?
<0.5ml/kg/hour
Antiotensin II and arteriolar vasoconstriction and ACEi’s
ACE inhibitors reduce Angiotensin II. Angiotension II mediates arteriolar vasoconstriction therefore increasing GFR. ACE I therefore can cause a fall in GFR by causing effferent arteriolar vasodilation.
Why can volume depletion/sepsis cause AKI?
Volume depletion/sepsis lead to decreased effective intravascular volume
This leads to increased ADH & aldosterone
Salt and water are retained
Then you get OLIGURIA
= AKI!
Untreated pre-renal AKI leads to what?
Acute tubular necrosis
What is the commonest form of AKI in hospital?
Acute tubular necrosis
Commonest causes of acute tubular necrosis?
Sepsis and severe dehydration
-other causes include rhabdomyolosis and drug toxicity
Treatment for pre-renal AKI?
- Access for hydration
- Fluid challenge for hypovolaemia
How would you assess for hydration?
Clinical observations (BP, HR, UO)
JVP, capillary refill time, oedema
Pulmonary oedema
What is the fluid challenge for hypovolaemia in AKI?
Crystalloid (0.9% NaCl) or Colloid (gelofusin)
DO NOT USE 5% DEXTROSE
Give a bolus of fluid and then reassess and repeat as necessary
If >1000mls IN and no improvement, seek help!!
Cast nephropathy is a typical renal complication found in patients with which condition?
Multiple myeloma
Diseases causing inflammation or damage to cells causing AKI?
RENAL AKI
Vascular causes of renal AKI?
Vasculitis
Renovascular disease
Glomerular causes of renal AKI?
Glomerulonephritis
Interstitial nephritis causes of renal AKI?
Drugs
Infection (TB)
Systemic (sarcoid)
Tubular injury as cause of renal AKI?
Ischaemia—prolonged renal hypoperfusion
Drugs (gentamicin)
Contrast
Rhabdomyolysis
Signs and symptoms of AKI?
Non specific symptoms
Anorexia, weight loss, fatigue, lethargy Nausea & Vomiting Itch Fluid overload Oedema, SOB
Signs
Fluid overload incl HTN, Oedema, Pul oedema, effusions (pleural & pulmonary)
Uraemia incl itch, pericarditis
Oliguria