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child health > GI disorders Part 3 > Flashcards

GI disorders Part 3 Flashcards

1
Q

what is the correlation between infection and allergy ?

A

there is a negative correlation

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2
Q

what is eosinophilic esophagitis ?

A

immune/antigen mediated disease
clinically - esophageal dysfunction
histologically - eosinophil-predominant inflammation

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3
Q

what are the symptoms of eosinophilic esophagitis ?

A

dysphagia to solid foods
feeding dysfunction
co-existing with some sort of atopy like allergic rhinitis

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4
Q

what are the diagnostic criteria of eosinophilic esophagitis ?

A
  1. symptoms related to esophageal dysfunction
  2. esophageal biopsy shows an eosinophil count above >15 eosinophils
  3. exclusion of other causes
  4. increased serum IgE and peripheral eosinophilia
    diagnosis must be made by endoscopy and biopsy
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5
Q

what does endoscopic appearance show in eosinophilic esoph ?

A

trachealization of the esophagus

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6
Q

what is the most common and imp differential diagnosis of EE ?

A

GERD

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7
Q

how are EE and GERD mainly differentiated ?

A

EE affects the proximal esophagus whilst GERD affects the lower esophagus
on biopsy there is no infiltration of eosinophils in GERD

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8
Q

what is the treatment for esinophilic esophagitis ?

A

avoidance of allergen
acid suppression using PPIs
steroids

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9
Q

when is an upper endoscopy indicated ?

A

in patients with a history of food impaction

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10
Q

what is the difference between food intolerance and food allergy ?

A

non-immunological hypersensitivity to a certain food

food allergy is a pathological immune response

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11
Q

how is a diagnosis of CMPA made ?

A 
skinn prick test 
RAST test ( specific IgE)
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12
Q

what is the management of CMPA ?

A

avoidance of the food
hydrolyzed milk or amino acid formula for infants
mild reaction - antihistamine
severe reaction - must carry an epi pen

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13
Q

what is the pathophysiology in celiac disease ?

A

gluten associated enteropathy

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14
Q

what labs are important for the diagnosis of celiac ?

A

IgA-tTga

EMA

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15
Q

what is the genetic predisposition in celiac disease ?

A

HLA-DQ2

HLA - DQ 8

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16
Q

what is found on endoscopy in a celiac disease patient ?

A

villous atrophy and mucosal damage

17
Q

what disease is associated with zinc malabsorption ?

A

acrodermatitis enteropathica

18
Q

what is the course of celiac disease ?

A

life long autoimmune condition

19
Q

what is the nature of anemia associated with celiac disease ?

A

resistant to therapy - due to malabsorption of enteric iron

improves with a gluten free diet

20
Q

what are the associated conditions with celiac disease ?

A 
T1DM 
autoimmune hypothyroidism 
dermatitis herpetiformis 
selective IgA deficiency 
Turners 45 XO
williams deletion on chrom 7 
downs T 21
21
Q

what is the definitive treatment for celiac disease ?

A

strict gluten free diet

child health (40 decks)

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