GI disorders part 2 Flashcards
what is the criteria required to diagnose childhood FAP ?
- must have episodic or continuous abdominal pain
- insufficient criteria for other FGID
- no evidence of any anatomical, inflammatory or neoplastic cause
must be fulfilled once per week for more than 2 months
what is the criteria for the diagnosis of FAP syndrome ?
some loss of daily functioning
additional somatic symptoms
what is the most common clinical presentation of FAP ?
more in girls 8-9 years gradual onset not related to eating, activity or bowel opening headache is common
once FAP is diagnosed what are the alarming features that could suggest an organic cause ?
less than 5 years pain away from the umbilicus nocturnal pain waking the child up fever, weight loss , hematemesis urinary symptoms blood in stool FH of IB , peptic ulcer
what is the management in FAP ?
symptomatic attempt to alleviate the pain
antispasmodic
antidepressant - amitriptyline
anti seizure drugs - gabapentin
what does infantile colic look like ?
paroxysmal , inconsolable crying or screaming several times a day often accompanied by:
drawing up to the knees
passage of excessive flatus
what is the management for infantile colic ?
reassurance
if it persists consider CMPA or GER
give trial of hydrolyzed formula followed by antireflux regimen
what is the distribution of affection in Crohn’s disease vs ulcerative colitis ?
Crohns: panenteric, perianal disease
UC : colon only
what is the pathology associated with Crohns vs UC ?
Crohns : skip lesions, transmural , granuloma
UC : diffuse , mucosal, crypt abscesses
what are the clinical manifestations of Crohn’s disease ?
lethargy and generally ill without GIT symptoms
triad of : abdominal pain, diarrhea and weight loss
along with extraintestinal manifestations : joints, eyes and oral and skin lesions ( uveitis, erythema nodosum, perianal skin tags )
what specific physical findings may be found in Crohn’s disease ?
orofacial granulomatosis
aphthous ulcers
pyostomatitis vegetans
angular chelitis
what are the phenotypes in distribution of Crohn’s disease ?
L1: distal ileum L2 : colonic L3: illio-colonic L4 : upper disease L4 a: proximal to treitz L4 b: distal to treitz
what is the first line management to induce remission in Crohn’s disease ?
enteral nutrition
prednisolone
5 ASA
what is the second line treatment for early relapse or treatment resistant cases in Crohn’s disease ?
Azathioprine
Methotrexate
what is the third line treatment for treatment resistant cases in Crohn’s disease ?
infliximab
surgery