Genetics of inflammation Flashcards
What are the types of genetic autoimmune disease
Polygenic autoinflammatory diseases
Mixed pattern diseases
Classic polygenic autoimmune diseases
Give examples of a polygenic autoinflammatory diseases
Crohn’s
Ulcerative colitis
Give examples of mixed pattern diseases
Psoriasis
psoriatic arthiritis
Give examples of classic polygenic autoimmune diseases
Systemic lupus
Erythematosus
What are the types of inflammatory bowel disease and what is the difference between them
Ulcerative colitis (inflammation and ulcers in mucosa of the colon only)
Crohn’s Disease (inflammation of all layers of GI tract)
What are the 4 causes of inflammatory bowel disease?
Persistent infection
Defective mucosal integrity
Dysbiosis (decrease of health bacteria)
Disregulated immune response