Genetics of inflammation Flashcards

1
Q

What are the types of genetic autoimmune disease

A

Polygenic autoinflammatory diseases

Mixed pattern diseases

Classic polygenic autoimmune diseases

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2
Q

Give examples of a polygenic autoinflammatory diseases

A

Crohn’s

Ulcerative colitis

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3
Q

Give examples of mixed pattern diseases

A

Psoriasis

psoriatic arthiritis

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4
Q

Give examples of classic polygenic autoimmune diseases

A

Systemic lupus

Erythematosus

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5
Q

What are the types of inflammatory bowel disease and what is the difference between them

A

Ulcerative colitis (inflammation and ulcers in mucosa of the colon only)

Crohn’s Disease (inflammation of all layers of GI tract)

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6
Q

What are the 4 causes of inflammatory bowel disease?

A

Persistent infection
Defective mucosal integrity
Dysbiosis (decrease of health bacteria)
Disregulated immune response

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