Gastric Cancer Flashcards

1
Q

What types of cancers are the majority of gastric cancer?

A

Adenocarcinoma (90%)

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2
Q

Where is the highest incidence of gastric cancer?

A

-east asia, eastern Europe and south america

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3
Q

What are the risk factors for gastric cancer?

A
  • consumption of smoked and salted foods
  • H. pylori infection
  • smoking
  • genetics
  • PUD doesn’t increase risk
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4
Q

What is the pathophysiology of gastric cancer?

A
  • loss of p53

- oncogenes, ras, c-myc, HER2

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5
Q

What are the classifications of gastric cancer?

A
  • according to location in the stomach, gross and histologic morphology
  • diffuse morphology: diffuse, infiltrative growth pattern, occurs in younger people, worse prognosis
  • intestinal morphology: bulky tumours composed of glandular structures
  • other types can by lymphoma
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6
Q

What are key diagnostic factors in gastric cancer?

A
  • abdominal pain worse with eating and vague
  • weight loss
  • dysphagia
  • nauseas
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7
Q

What are investigations for gastric cancer?

A
  • gastroscope
  • CT
  • CXR (metastatic lesions)
  • PET
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8
Q

How is it staged?

A

TNM system

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9
Q

What are DDx for gastric cancer?

A
  • PUD
  • Benign oesophageal strictures
  • Achalasia
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10
Q

What is the treatment for gastric cancer?

A
  • localised malignancy is surgery and chemo,radiotherapy

- if not localised then chemoradiation

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