Fungal infections Flashcards
Fungal cell walls are made up of which 3 main molecules cross linked?
Glycoprotein
Glucan
Chitin
What happens if the components of fungal cell wall is disrupted?
Osmotically unstable
Causes lysis and death
The main sterol in mammal cell membranes is cholesterol. What is the main sterol in fungi?
Ergosterol
Some antifungal drugs inhibit or induce which enzyme? How does this affect the metabolism?
Cytochrome P450
Inhibits - decreases metabolism, potentially toxic
Induces - increases metabolism, less effective
Give an example of a superficial fungal infection
Dermatophytosis (ring worm)
Fungi are opportunistic saprophytes (feed on decaying matter). They can also be opportunistic infections from commensal fungi. Give an example of a fungi that is commensal
Malassezia pachydermatis
What is malassezia dermatitis and otitis? Which fungi is responsible for this?
Overgrowth of yeast
Malassezia pachydermatis
Where is Malassezia pachydermatis usually found (commensal fungi)?
Mucosal surfaces
Skin
Ear canals
Malasezzia dermatitis and otitis is usually secondary to underlying disease. What does proliferation of M.pachydermatitis cause?
Inflammation and pruritis of skin, ear canals and mucosal surfaces
What is correct name for ringworm?
Dermatophytosis
What fungi is responsible for ringworm/dermatophytosis?
Malasezzia canis
Is ringworm zoonotic? when is it more common?
Yes
In underlying disease or predisposed breeds (Yorkies)
What are the reservoirs of infection for dermatophytosis?
Environment
Asymptomatic cats
How can dermatophytosis be prevented?
Bovillis ringvac immunisation
Prophylaxis
How can dermatophytosis be treated? How often?
Lime sulfur dips
Twice weekly
