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ID > Feline infectious peritonitis (FIP) > Flashcards

Feline infectious peritonitis (FIP) Flashcards

1
Q

What viruses causes FIP?

A

Feline corona virus (FCoV)

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2
Q

Do all cats with FCoV develop FIP? What type of cats usually develop FIP?

A

No

Tend to be disease of cats group together

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3
Q

FCoV is a large enveloped virus. Is it RNA or DNA?

A

RNA

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4
Q

What are the 2 types of FCoV?

A

Feline infectious peritonitis virus (FIPV)

Feline enteric coronavirus (FECoV)

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5
Q

Why are feline corona viruses highly evolving?

A

High mutation rates

No RNA polymerase proof reading

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6
Q

What factors determine whether a cat infected with FCoV develops FIP?

A

Immune status
Virus biotype
Route of infection
Dose of infection

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7
Q

What symptom does FECoV cause? How can FECoV become FIP?

A

Mild D+
Transmission via intestinal shedding
Mutates to become FIP

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8
Q

How is FCoV transmitted in kittens?

A

Faeces

Saliva

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9
Q

FIPV is very virulent. It doesn’t replicate in the intestines and it isn’t shed. Where is FIPV found (and replicate)?

A

Enterocytes

Macrophages (Ab binding to virus enhances uptake)

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10
Q

Where does FECoV replicate?

A

Enterocytes

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11
Q

Why might a cat not develop FIP?

A

If it has no antiviral antibodies

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12
Q

Do Abs given in a vaccination for FIP work?

A

No speed up disease

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13
Q

What are the clinical signs of FIP

A 
Mild entertitis 
Wet FIP (fatal)
Dry FIP (fatal)
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14
Q

What are the clinical signs of wet FIP?

A 
Ascites 
Depression 
Lethargy 
Weight loss
Jaundice 
Hepatomegaly
Dyspnoea
Pyrexia
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15
Q

What are the clinical signs of dry FIP?

A

Depression, lethargy, jaundice, hepatomegaly, dyspnoea

No ascites or fluid accumulation

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16
Q

How is FIP diagnosed? (Difficult)

A

Histopathology
Clinical signs
FCoV serology (Ab does not mean FIP)
Viscous, straw coloured fluid, high protein content, froths if shaken, clots on standing

17
Q

What does the haematology of an animal with FIP show?

A

Neutrophilia
Lymphopenia
Mild non-regenerative anaemia

18
Q

What is Rivalta’s test? Is it accurate?

A

Add vinegar to fluid
Positive result - precipitate forms on surface and sinks to bottom of tube
Not 100%

19
Q

What is the treatment for FIP?

A

No treatment

Some claim interferon prolongs life but probably misdiagnosed

20
Q

Most multicast households are seropositive of FCoV. How can infection in kittens be prevented?

A 
Isolate queens prepartum 
Wean early 
Isolate kittens
Hygiene 
Reduce number of cats
21
Q

What is the pathogenesis of FCoV (leading to FIP)?

A

FECoV shedding cat passes FECoV to another
Causes oronasal infection
Moves to tonsils, URT and intestinal epithelium
Sporadic mutation to FIPV FIPV enters macrophages

22
Q

How does the status of a cat’s cell mediated immunity influence their outcome from FECoV infection?

A

Good CMI = recovery
Partial CMI = dry FIP
Poor CMI = wet FIP

ID (20 decks)

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