Flashcard 5
what happens between endothelial cells of arterioles in diabetes mellitus
subendothelial accumulation of plasma proteins and connective tissues
direct effects of GH on regulation of metabolism
increases gluconeogenesis
reduces insulin ability
makes adipocytes more sensitive to lipolytic stimuli
increased amino acid uptake and protein synthesis
actions of growth hormone
- repair and maintain damaged cells
- regulation of metabolism
- growth and development
lipolysis
formation of ketones from fatty acids
examples of drugs that can cause obesity
- anti-psychotics
- steroids
- insulin
- antithyroid drugs
- sodium valproate
difference between hypothyroid dwarfism and other types of dwarfism
normal dwarfism - everything adult like in small proportion
hypothyroid - everything still child-like
what effect does regular exercise have on insulin sensitivity
produces prolonged sensitivity to insulin
functions islets of langerhans
endocrine - produce hormones
can peptide hormone be orally
no
what % diabetic patients are insulin resistant
90%
complicated explanation of primary action of insulin
binds to tyrosine kinase receptor on the cell membrane of insulin sensitive tissues to increase the glucose uptake by these tissues
name of testical measuring device
orchidometer
factitious hypoglycaemia
high insulin levels in the absence of elevated c-peptide concentration
what is insulins mode of action in muscle and adipose tissue
stimulates mobilisation of SGLT1, transporting glucose into cell
are most of insulins activities anabolic or catabolic
anabolic
DHEA
dehydroepiandrosterone
prehormone of oestrogen and testosterone
what do tropic hormones do after they have been produced by the hypothalamus
go to anterior pituitary to regulate release of endocrine hormones
origin anterior pituitary tissue
epithelium
how much of the pancreas operates as endocrine
1%
indicators for concern regarding child growth
outwith parental target range
very tall/ very short
pancreatic polypeptide function
may help control of nutrient absorption from GIT
