FINAL EXAM LECTURE Flashcards
Be able to name the endocrine glands and identify where they’re located at in the body
pineal gland, hypothalamus, pituitary gland, thyroid gland,
parathyroid glands, thymus, adrenal glands, pancreas and gonads (ovary and testis)
What are hormones?
Chemical messengers (usually long-distance chemical signals that
travel in blood or lymph throughout the body) that bind to receptors on target cells to
cause a specific physiological reaction. Target cells have receptors that only respond to
specific hormones.
What are autocrines?
Short distance chemical signals that exert their effects on the same
cells that secrete them (example is prostaglandins released by smooth muscles that cause
those smooth muscle cells to contract).
What are the types of stimuli that trigger endocrine glands to manufacture and release their
hormones?
The release of hormones is controlled by humoral, neural, hormonal
mechanism
How does the hypothalamus interact with the anterior pituitary?
There is a blood connection
between the hypothalamus and the anterior pituitary gland and releasing and inhibiting
hormones are released.
What hormones are released from the anterior pituitary gland?
Growth hormone (GH), thyroid-stimulating hormone (TSH), adrenocorticotropic
hormone (ACTH), follicle-stimulating hormone (FSH), luteinizing hormone (LH), and
prolactin (PRL)
How does the hypothalamus interact with the posterior pituitary?
There is a nerve
connection between the hypothalamus and the posterior pituitary gland. Hypothalamus
neurons synthesize hormones and they are released from the posterior pituitary gland
What hormones are released from the posterior pituitary gland?
Oxytocin and antidiuretic
hormone.
What is the function of oxytocin and where is the target receptor for this hormone?
Oxytocin
is the hormone responsible for causing uterine smooth muscle to cause labor
contractions. It also initiates milk ejection in the breast.
1
What homeostatic imbalance occurs when there is a decrease in ADH?
Diabetes insipidus
when a patient is dehydrated, blood pressure may drop. ADH is also inhibited by urine
so this will produce large amounts of urine
What homeostatic imbalance occurs when there is a decrease in GH?
Pituitary dwarfism in
children.
What homeostatic imbalance occurs when there is an increase in GH?
Gigantism
in children and acromegaly in adults
What homeostatic imbalance occurs when there is an increase in TSH?
Hyperthyroidism,
exophthalmos is seen in patients with hypersecretion of thyroxine, also can cause
Graves’ disease when antibodies mimic TSH.
What homeostatic imbalance occurs when
there is a decrease in TSH?
Hypothyroidism, may cause myxedema
Iodine is the central ion in the both thyroid hormones. What can result from a deficiency in
iodine?
Formation of a thyroid goiter
How are the thyroid hormone produced (thyroxine -
T4 and triiodothyronine- T3)?
Produced in the colloid and then taken into the follicular
cell by endocytosis
What homeostatic imbalance occurs when there is an increase in ACTH?
Cushing’s disease
What are the symptoms of this disease or syndrome?
Increased glucose levels, tissue
swelling
What is the function of FSH in females?
Maturation of the oocyte
What is the function of
FSH in males?
Maturation of the sperm
What is the function of LH in females?
Ovulation
What is the function of LH in males?
Sperm production so a male with low LH will have a low sperm count
FSH and LH are referred to as gonadotropins because they stimulate the gonads.
true
What is the function of PRL?
Increase milk production in the lactating breast
milk production in the lactating breast
What is the function of calcitonin and parathyroid hormone (PTH)/parathormone?
Both of
these hormones regulate calcium metabolism. Calcitonin is produces by the
parafollicular cells (C cells) of the thyroid gland. Calcitonin can have a bone-sparing
effect at higher doses therefore inhibiting osteoclast activity to inhibit bone resorption
and stimulate calcium uptake from the blood into the bony matrix. PTH causes serum
calcium levels to stimulating osteoclast activity and bone deposition.
What are the layers of the adrenal cortex and what hormones are produced from each layer?
The outermost is the zona glomerulosa which produces aldosterone (a
mineralocorticoid). The middle layer is the zona fasciculata which produces cortisol (a
glucocorticoid). The innermost layer is the zona fasciculata which produces androgens.
What happens if there is a tumor in the zona fasciculata that causes hypersecretion of
hormones produced in that region?
There is an increase in cortisol (glucocorticoids).
What
is the function of these hormones?
Glucocorticoids enable the body to deal appropriately
with stress. They do this by increasing blood glucose levels and blood pressure.
Which layer of the adrenal gland is responsible for the fight/flight/fright response and what
does it produce?
The adrenal medulla is the innermost region of the adrenal gland and it
produces epinephrine and norepinephrine.
Which of hormone will cause dilation of bronchi, dilation of the pupil and increase in heart
rate and would be released if blood volume has sudden become low due to a catastrophic
injury (like a bad car accident)?
epinephrine
Be sure to understand the differences between the short-term and long-term stress response
from the adrenal gland (see Focus Figure 16.2
What is a hypersecretion of hormones from the medulla of the suprarenal gland due to a tumor
called?
Pheochromocytoma
What hormone will be affected by this tumor?
Epinephrine
and causes hypertension
What hormone is produced by the pineal gland and what is its function?
Produces melatonin
which is produced when there is an absence of light (darkness). Therefore, melatonin
helps to signal the brain to start fall asleep
What time of year would you expect people to have higher levels of melatonin?
In the winter
because there is an absence of light.
The pancreas secretes 2 important hormones that control glucose regulation. What are the two
hormones, the cells within the pancreas that produce them and what is the effect on glucose
regulation?
Glucagon is secreted by alpha cells, it increases blood glucose by releasing
glucose from the liver cells. It does this through glycogenolysis (breakdown of glycogen
to glucose) or gluconeogenesis (synthesis of glucose from non-carbohydrate molecules).
Insulin in secreted by beta cells it decreases blood glucose by transporting glucose into
most body cells, especially muscle and fat cells. It also inhibits the breakdown of
glycogen into glucose and inhibits the conversion of amino acids or fats to glucose.
Which pancreatic hormone would be released if you have just had a large meal of sugary
calories?
Insulin lowers the blood glucose levels therefore it is referred to as a
hypoglycemic hormone
Which pancreatic hormone would be released if you haven’t eaten for 8-10 hours?
Glucagon
raises the blood glucose levels therefore it is referred to as a hyperglycemic hormone
What is diabetes mellitus and what are the two types of diabetes mellitus?
Diabetes mellitus
means there is sugar in the urine (whereas diabetes insipidus is very dilute urine due to a
lack of ADH). In diabetes mellitus type 1, insulin is absent so there has to be complete
insulin supplementation. In diabetes mellitus type 2, insulin is present but its effects are
deficient because there are problems with the pancreas producing the insulin. Diabetes
mellitus type 2 it is most often seen in older patients, pancreatic islets (also called Islets
of Langerhans) are not able to produce insulin, most insulin secretion is inadequate, and
most patients are obese. In both cases, blood glucose levels remain high after a mean
because glucose in unable to enter most tissue cells.
What is the name of the gut of continuous muscular tube that winds through the body from the
mouth to the anus?
Alimentary canal
What are the names of GI tract in order?
Mouth, pharynx, esophagus, stomach, small
intestine, and large intestine
What are the names of the accessory digestive organs?
Teeth, tongue, gallbladder, salivary
glands, liver and pancreas.
What is the term that describes the sequence of steps in which large food molecules are
broken down to their building blocks by enzymes is called?
Chemical digestion
That is the term for passage of digested end products from the lumen of the GI tract through
the mucosal cells?
Absorption
What term describes the major means of propulsion, involving alternative waves of
contraction and relaxation of muscles in the organ walls?
Peristalsis
What are the 4 layers of the GI tract?
From inside the mucosa, submucosa, muscularis
externa and serosa
Where in the alimentary canal are these 4 layers located?
Extends from
the esophagus to the anal canal.