Feed (pasture, grain) associated with Laminitis in Horses

Question 1

What type of performance horse usually get laminitis?

Answer 1

Dressage

Question 2

What are the 2 main causes of laminitis?

Answer 2

1. Carb overload

2. Obesity/ EMS/ PPID and insulin resistance (and laminitis)

Question 3

What is carb overload also known as?

Answer 3

Pasture associated laminitis

Grass founder

Question 4

Aetiology of carb overload

Answer 4

Starch/ fructose i.e oligofructose- alters the microbial flora- incr lactic acid production- decr in the intraluminal pH– incr intestinal permeability and osmotic P which leads to entry of:

1. endo and exotoxins
2. vasoactive amines
3. bact by products

The 3 of these cause a systemic inflamm response– insulin resistance— LAMINITIS!!

Question 5

Aetiology of Obesity + EMS + PPID and insulin resistance

Answer 5

Obesity: proinflamm state- TNF alpha secreted by adipose
Insulin: VasoC. incr adhesion molecules on endothel– migration of Ne to the laminar tissues
Platelet activation by biogenic amines and intestinal endotoxins

Question 6

Qhat is insulin resistance?

Answer 6

When the normal amount of insulin is unable to remove glucose fromt he blood and into: muscle, fat, liver. The pancreas secretes more insulin to compensate- this causes hyperinsulinaemia

Question 7

Causes of hyperinsulinaemia/ Insulin resistance

Answer 7

1. PPID
2. Corticosteroids
3. Genetic
4. Obesity
5. Lack of exercise
6. High ESC/NSC and starch diet