Exam 2: Chapter 48 - Obesity Flashcards
What is obesity?
abnormal or excessive fat accumulation that may impair health
Obesity is a BMI above
39 mg/m2
Percentage of poeple who are overweight or obese?
68.5%
Who has a higher prevelance for obesity?
Prevelance higher in women, African American, and Hispanic
Increased risk for
disease, disorders, low self-esteem, impaired body image, depression, and diminished quality of life
Dysfunctional adipose tissue cells release
biochemical mediators that cause chronic inflammatory changes, which can lead to a multitude of diseases, including heart disease, hypertension, and type 2 diabetes.
Increase in fat stores, or adipose tissue, result in increases in the hormone
leptin, which is secreted by fat cells. Leptin also has the effect of signaling satiety in the hypothalamus.
Treatment of obesity generally includes
lifestyle modifcations, pharmacological management, and nonsurgical or surgical interventions
What lifestyle modications can be done?
Most effective behavioral interventions are those considered high intensity. Having 12-26 sessions annually.
They should also plan to cut 500-1000 calories daily.
Pts who are not successful at meeting weight loss goals from lifestyle modication alone may be prescribed
Antiobesity Medications
These should be used to lower BMI in long term and are meant to supplement diet modification and exercise.
Gastrointestinal Lipase Inhibitor: Mechanism of Action
Diminishes intestinal absorption and metabolism of fats, particularly triglycerides
Gastrointestinal Lipase Inhibitor: Adverse Effects
Diarrhea, Flatus, Oily Stools, Fecal Incontinence Great for those who want to lose weight. People had these symtpoms eating potato chips
How do antiobesity medications work?
By inhibitin gastrointestinal absorption of fats, or by altering central brain receptors to enhance satiety or reduce cravings
Needs to lose at least 5% of body weight after 12 weeks.
Minimally invasive Interventions include
Vagal Blocking (Neurometabolic Modulation) and
Intragastric Balloon Therapy
What does Vagal Blocking Therapy consist of?
Involves placement of a pacemaker like device into subcutaneous tissue in the lateral thoracic cavity with two leads that are laparoscopically implanted at the point where the vagus nerve truncates at the gastroesophageal junction
Pulsing signal sent for 12 hours daily. This causes blocking of vagus nerve resulting in diminished gastric contraction and emptying resulting in increased dsatiety and decreased cravings
What is Intragastric balloon therapy
involves endoscopic placement of a saline-filled balloon or saline-filled dual ballon into the stomach. Cause increased feelings of satiety and decreased gastric emptying.