Exam 1: Magnesium Imbalances Flashcards
What does Magnesium do?
Acts as an activator for many intracellular enzyme systems and plays a role in both carbohydrate and protein metabolism.
Normal Magnesium level?
1.3-2.3 mg/dL
Where does Magnesium go?
1/3 bound to protein, and 2/3 exist as free cations.
What happens with variations of Magnesium?
It affects neuromuscular irritability and contractility
What happens with excess magnesium?
It diminishes the excitability of the muscle cells
What happens with deficit of magnesium
Deficit increases neuromuscular irritability and contractility.
Magnesiums affect on cardiovascular system?
They act peripherally to produce vasodilation and decreased peripheral resistance.
Hypomagnesemia Range?
<1.8 mg/dL
Hypermagnesemia Range?
> 3.0 mg/dL
Hypomagnesemia Contributing Factors
Chronic Alcholism, Hyperparathyroidism, Diabetic Ketoacidosis, Refeeding after Starvation, Chronic Laxative Use , Heart Failure
Hypomagnesemia Signs/Symptoms
Neuromuscular Irritability, Positive Chvostek and Trousseau Sign, Mood Changes, Anorexia, Vomiting, Increased BP
Hypermagnesemia Contributing Factors
Oliguric Phase of Acute Kidney Injury
Adrenal Insufficiency, Excessive IV Magnesium, Hypothyroidism
Hypermagnesemia Signs/Symptoms
Fluishing, Hypotension, Muscle Weakness, Drowsiness, Hypoactive Reflexes, Depressed Respirations, Cardiac Arrest
What is Hypomagnesemia commonly associated with?
Hypokalemia and Hypocalcemia . They must all be address concurrently
What similarity does Hypomagnesemia share with Calcium
- It is the ionized frction of magnesium tha tis primarily involved in neuromuscular activity and other physiologic process
- Magnesium levels should be evaluated in combination with albumin levels
Hypomagnesemia Route?
Magnesium loss occurs in the GI Tract. This includes nasogastric sunction, diarrhea, or fistulas
Hypomagnesemia: Where is the major site of magnesium absorption?
the distal small bowel. Any disruption can lead to hypomagnesemia.