Exam 2: Chapter 47 - Malabsorption

Question 1

What is Malabsorption

Answer 1

The inability of the digestive system to absorb one or more of the major vitamins (especially A and B12), minerals (Iron and Calcium) and Nutrients occurs in disorders of malabsorption

Question 2

Conditions of Malabsorption?

Answer 2

Mucosal (Transport) Disorders: Cause generalized malabsorption

Luminal Disorders: Cause malabsorption

Lymphatic Obstruction, interfering with transport of fat by products of digesetion into the systemic circulation Postoperative Malabsorption

Question 3

What is Celiacs Disease?

Answer 3

Disorder of malabsorption caused by an autoimmune response to consumption of products that contain teh protein gluten.

Question 4

Gluten is most commonly found in

Answer 4

what, barley, rye, and other grains, malt, dextrin, and brewers yease

Question 5

What does those who are predisposed to Celiac have?

Answer 5

Have major distocompatibility complex (MHC) Class II Allele Human Leukocyte Antigen (HLA), HLA-DQ2 or HLA-DQ8

Question 6

Those who develop celiac disease exhibit an autoimmune repsonse to gluten products that is what type of immunity?

Answer 6

Humoral and Cell Mediated

Question 7

What happens in an autoimmune response to gluten?

Answer 7

Epithelial cells that line the small inteestines become inflamed, particularly the proximal portion, where most absorption of nutrients occurs. This results in loss of ability to absorb both micronutrients and macronutrients, causing systemic nutritional deficits.

Question 8

Signs and Symptoms of Celiac Disease?

Answer 8

Diarrhea, Steatorrhea, Abdominal Pain, Abdominal Distention, Flatulence, and Weight Loss

For adults, this includes fatigue, general malaise, depression, hypothyroidism, migraine headaches, osteopenia, anemia, seizures, paresthesias and a red shiny tongue

Question 9

Tests to determine Celiac Disease?

Answer 9

SEries of serologic tests and endoscopic biopsy. Patient must continue to consue gluten during testing.