Exam 1: Chapter 53: Assessment of Kidney Functions Flashcards
Functions of Kidney
Urine Formation Excertion of Waste Products Regulation of Electrolytes Regulation of Acid-Base Control of Water Balance Control of Blood Pressure Renal Clearance Regulation of RBC Prod Synthesis of Vitamin D to Active Form Secretion of Prostaglandins
Urine Formation: Formed in
Nephrons through glomerular filtration -> tubular reabsorption and tubular secretion
Urine Formation: What is usually excreted in urine?
Sodium, Chloride, Bicarbonate, Potassium, Glucose, Urea, Creatine, and Uric Acid
Antidiuretic Hormone: Also known as
Vasopressin
Antidiuretic Hormone: What is this?
Secreted by posterior portion of pituitary gland is response to changes in osmolality in blood .
Antidiuretic Hormone: With decreased water intake, what happens to blodo osmolaity?/
Increased. This stimulates ADH reelase
Antidiuretic Hormone: Acts on what organ ____ and does ___
kidney, increase reabsorption fo water and returning osmolality of blodo to normal
Antidiuretic Hormone: Excess water intake leads to
secretion of ADH, and leads to diuresis (increased urine volumme)
Antidiuretic Hormone: A dilute urine with SpG of 1.010 and osmolality of 300 mOsm/L indicates
inability to concentrate and dilute urine
Osmolarity: This refers to
the ratio of solute to water
1 lb of fluid equal to ? mL
500 mL
Regulation of Electrolyte Excretion: With increased aldosterone in the blood.
less sodium is excreted in the urine
Regulation of Electrolyte Excretion: Release of Aldosterone form adrenal cortex largely under control of
Angiotensin II
Regulation of Electrolyte Excretion: RAAS activated when
pressure in the renal arterioles falls below nromal levels . Occurs with shock, dehydration, or decreased sodium chloride delivery
Regulation of Acid-Base: Normal serum pH is
7.35 - 7.45
Regulation of Acid-Base: One of kidneys function to keep this balanced is to
reabsorb and reutrn ot the body circulation any bicarbonate from the urinary filtrate
Autoregulation of Blood Pressure: Specialized vessels of the kidney called vasa recta monitor
blodo pressure as blood begins passage into the kidney
Autoregulation of Blood Pressure: When vasa recta detect decrease in blood pressure,
afferent artiole, distal tibule and juxtaglomerular cells secrete renin
Autoregulation of Blood Pressure: Renin convets
Angiotensinogen into Angiotensin I, which is then converted in Angiotensin II. This causes blood pressure to increase
Autoregulation of Blood Pressure: Adrenal cortex secretes aldosterone in response to
stimulation by pituitary gland , which occurs asresponse to poor perfusion or increasing serum osmolality. results in increase of bp
Autoregulation of Blood Pressure: Failure to stop Renin is one of the primary causes of
hypertension
Renal Clearance: This refers to
the ability of the kidney to clear solutes from the plasma
Renal Clearance: Primary test?
24 hour collection of urine used to evaluate how well the kidney performs
Renal Clearance: Renal clearance depends on what several factors?
How quickly substance is filtered across the glomerulus
how much the substance is reabsorbed along the tubules
how much the substance is secreted into tubules
Renal Clearance: One measure that is partically useful is?
Creatinine clearance
Renal Clearance: Creatinine is
an endogenous waste product that is filtered at the glomerulus. Hence why its a good measure of GFR, the amount of plasma filtered through the glomeruli per unit of time
Renal Clearance: Adult GFR can vary from
125-200 mL/min
Renal Clearance: AS renal function decline, what happens to creatinine and renal clearance?
decrease
Regulation of RBC Production: When kidneys detect decrease in oxygen tension in renal blood flow because of anemia, arterial hpoxia, or inadequate blood flow, they reelase
erythropoietin
Regulation of RBC Production: What is Erythropoietin?
Glycoproetin from the kidney that stimulates the bone marrow to produce red blood cells
Vitamin D Synthesis: Kidneys response for final conversionof
inactive vitamin d to its active form 1,25-dihydroxycholecalciferol
Vitamin D Synthesis: Vitamin D is necessary for maintaining
normal calcium balance in the body
SEcretion of Prostaglandins and other substances: What do this do?
Help afferent and efferent arterioles maintain renal blood flow by causing selective vasodilation or vasoconstriction
Excretion of Waste Products: Major waste product of body?
Urea. 25-30 g excreted daily.
Urine Storage: Filling and emptying of the bladder are mediated by coordinated
sympathetic and parasympathetic nervous system control of mechanisms involving the detrouser muscles and the bladder outlet
Urine Storage: At night, the reelase of vasopressin causes
decrease in the production of urine and makes it more concentrated. Thats why we dont pee at night
Common Symptoms - Pain: Genitourinary pain usually caused b
distention of some portion of urinary tract bc of obstructed urine flow or inflammation and swelling
Urinalysis: What does this provide?
Clinical information about kdiney function and helps diagnose other diseases such as diabetes
Urine Culture: Determines whether
bacteria are present in urine, as well as their strains and concentration
Urinalysis and Urine Culture: Hematuria common causes include
acute infection (cystitis, urethritis, or prostatitis), renal calculi or neoplasm
Urinalysis and Urine Culture: What test should be done to test for protein?
Dipstick examination, because urine concentration, pH, hematuria, and radiocontrast materials all affect the results
Urinalysis and Urine Culture: Causes of persistent proteinuria include
glomerular diseases, malignancies, collagen dsieases, diabetes, preeclampsia, hypothyroidism, heart failure, exposure to heavy metals and use of medications
Specific Gravity: SpG of water?/
1.000
Specific Gravity: When fluid intake decreaes, SpG..
increases
Specific Gravity: With high fluid intake, SpG…
decreaes
Specific Gravity: Methods for Testing?
Multiple Test Dipstick (Most Common)
Urinometer (Least)
Refractometer
Specific Gravity: Patients with kidney disease and fluid intake
it does not vary and patients urine is said to have fixed specific gravity
Specific Gravity: Disorders that cause decreased SpG include
diabetes, glomerulonephritis, and severe renal damage
Specific Gravity: Increased SpG caused by
diabetes, nephritis, and fluid defific
Osmolaity: Most accurte measurement of
kidneys ability to dilute and concentrate urine . Measures number of solute molecules in a kilogram of water