Etomidate (Amidate)

Question 1

Class (2)

Answer 1

• Hypnotic

- Induction agent

Question 2

Actions (4)

Answer 2

• Ultra short-acting non-barbituate, non-benzodiazepine hypnotic with no analgesic effects
• May have GABA-like effects that depresses the RAS
• Minimal cardiovascular and respiratory effects
• Does not release histamine

Question 3

Indications

Answer 3

Facilitate RSI protocols

Question 4

Contraindications (2)

Answer 4

• Known hypersensitivity to barbituates

- Should not be used in children under 10 y.o.

Question 5

Use with Caution (4)

Answer 5

• May cause increasing airway resistance worsening bronchospasms in severe asthma
• Cardiovascular disease
• Hypotension
• Elderly

Question 6

Adverse Effects (8)

Answer 6

• Myoclonic/Tonic activity (common)
• Apnea
• Laryngospasms
• Hyper/hypoventilation
• Hyper/hypotension
• Tachy/bradyarrhythmias
• N/V
• Pain at the injection site

Question 7

Precautions (2)

Answer 7

• Flumazenil does not reverse Etomidate

- Verapamil may prolong respiratory depression

Question 8

Dosage/Route

Answer 8

• Adult 0.3 mg/kg (0.1-0.3 mg/kg IV over 15-30 sec)
• Onset of action begins within 10-20 sec
• Peaks within 1 minute and lasts for 3-5 minutes