Dextrose 50% Solution (D50)

Question 1

Class (2)

Answer 1

• Carbohydrate

- Antihypoglycemic

Question 2

Action

Answer 2

Rapidly increases blood sugar level

Question 3

Indications (3)

Answer 3

• Hypoglycemia
• AMS, etiology unknown
• SZ in diabetes

Question 4

Dosage/Route

Answer 4

25g IV

Question 5

Standard Prep

Answer 5

25g in 50cc preloaded syringe

Question 6

Peds Dose

Answer 6

• For newborns, 10% Dex solution 0.2g/kg dose IV; D50 solution 1 part to 4 parts NS. 0.2mg/kg is supplied by 2 ml/kg of D10W
• For infants and children <30kg, 25% Dex solution 0.5g/kg dose IV. Mix D50 with an equal volume of NS to provide D25. 0.5g/kg is supplied by 2 ml/kg of D25W.
• For all other children, 0.5g/kg (1 ml/kg of 50% Dex) up to a max of 25g

Question 7

Side Effects (3)

Answer 7

• Venous irritation
• Localized tissue necrosis
• Intracerebral hemorrhages in neonates

Question 8

Precautions

Answer 8

• Use large bore catheter
• Undiluted D50 in neonates causes intracerebral bleeds
• Should be preceded by thiamine (if available) in suspected alcoholic pts to avoid the possibility of inducing encephalopathy in thiamine deficient pts