Endotoxemia Flashcards
Endotoxemia
disregulated inflammatory response
-two opposing forces at the same time (clotting and bleeding)
How does endotoxemia start?
with gram (-) infections (generally in the GI tract)
What will the inflammatory response lead to?
SIRS = systemic inflammatory response system
What can happen when the mucosal barrier is compromised?
endotoxins can be translocated into the bloodstream
What causes endotoxemia?
-over-exercise or strenuous exercise
-severe trauma
What % of colic cases become toxic?
10-40%
What horse becomes toxic faster?
foals
Can endotoxemia lead to colic?
yes
Can colic lead to endotoxemia?
yes
Pathogenesis of endotoxemia:
- translocation of endotoxins
- activation of an inflammatory response (innate immune system)
- TxA2 promote platelet aggregation (clots) which leads to PGI2 + PGE2 leading to vasodilation and hypertension (low BP)
- systemic hypotension (leads to perfusion deficits and organ failure)
- coagulopathies leads to diseminated intravascular coagulopathy
Vasoconstriction leads to…
hypertension (increased BP)
Bronchoconstriction leads to…
dyspenea (difficulty breathing) which leads to hypoxemia
Endotoxemia will quickly lead to,,,
laminitis
Other factors of pathology:
-thrombocytopenia (low platelet circulating in blood)
-hypovolemia (low circulating blood)
-myocardialdepression
-vasoplegia (floppy vessels)
What is endotoxic shock?
blood pools in areas
