Endocrine System Flashcards
2 major control systems
nervous and endocrine system
electrochemical impulses
quick
nervous system
hormonal
slow, effects last longer than nervous system
endocrine system
2 major control systems linked by…
pituitary gland
hormones regulate (5)
Reproduction Growth and development Electrolyte, water, nutrient balance in blood Cellular metabolism and energy balance Body defenses
non-hormonal with ducts
examples: sweat, saliva, milk, earwax
exocrine glands
produce hormones no ducts (released into surrounding tissue fluid)
endocrine glands
Long-distance; travel via blood
hormones
Short-distance; exert effects on same cells secrete them (think autobiography)
autocrines
short-distance; exert effects on different types of cells in same tissue
paracrines
what determines hormone solubility in water
hormone structure
most common type
water soluble
cannot cross cell membrane (hydrophilic)
amino acid based hormones
cholesterol is…
steroid based
Synthesized from cholesterol
Lipid soluble (hydrophobic)
cross cell membranes
Travel in bloodby carrier protein
steroid based hormones
hormone can only influence cell if cell has a…
receptor for it
hormone can increase/decrease
rates of cell processes
response depends on
nature of target cell it binds to
5 things hormones do
open/close ion channels stimulate synthesis of enzymes/protein activate/deactivate enzyme induce secretion of other substances stimulate mitosis
water soluble
bind cell membrane receptors => Activate 2nd messenger systems
lipid soluble
cross cell membrane
bind receptor inside cell
directly activate genes for transcription
Protein kinases affect activity of other proteins (usually enzymes) by adding a…
phosphate to them
enzymatic cascade has a huge…
amplifying effect
The second messenger, cyclic AMP (cAMP), is degraded by
phospho-diesterase
steroids have to come in through the…
cell membrane
steroids directly activate
DNA
3 stimuli for endocrine glands
humoral
neural
hormonal
fluids
levels of ions or nutrients in blood (result: stimulate hormones)
humoral stimulus
example of humoral stimulus
not enough ca in blood
parathyroid secrete hormones
endocrine gland responds directly to neural impulse
sympathetic fiber
neuron stimulates adrenal medulla (epinephrine)
neural stimulus
sympathetic
fight or flight
adrenal gland
near your kidney
“Hypothalamic-pituitary-target endocrine organ feedback loop”
core of endocrinology
“Hypothalamic-pituitary-target endocrine organ feedback loop” is an example of
negative feedback
blood levels of hormones produced by target glands increase, they inhibit…
release of pituitary hormones stimulate release.
target cell must have blank to be bound to hormone
receptor
target cell activation depends on (3)
blood levels of hormone
# of receptors for hormone of target cell
“affinity” (Velcro) strength of hormone-receptor binding
hormone blood levels can fluctuate (T/F)
true
cells can “up-regulate” or “down-regulate”
of receptors
Hormone cannot exert full effect without other hormone
permissiveness
Combined effects of hormones are greater
synergism
hormone opposes other’s action
antagonism
hormone opposes other’s action
antagonism
blood levels/half-life of hormone based on (2)
release rate
speed of activation and removal from body
most hormones are removed by…
kidneys or liver (excreted in urine)
time it takes for the concentration to drop by half
half-life
pea size
Connected to hypothalamus
at least 8 hormones
posterior/anterior lobes
pituitary gland (hypophysis)
mostly nervous tissue
releases neurohormones received ready-made from hypothalamus
posterior pituitary–Hormone storage area
neurohormones
hormones made by neurons