Embryology of the CVS 2 Flashcards

1
Q

What is the definition of Vasculogenesis and angiogenesis?

A

Vasculogenesis: New formation of a primitive vascular network

Angiogenesis: The growth of new vessels from pre-existing blood vessels

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2
Q

What are the two first arteries seen?

A

•right and left primitive aortae

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3
Q

What are the components of each primitive aorta?

A

Ventral aorta and dorsal aorta

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4
Q

How is the aortic sac produced?

A

Fusion of ventral aorta

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5
Q

Where do aortic branches arise from?

A

The aortic sac

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6
Q

What are pharyngeal arteries?

A

Supply pharyngeal arches

Communicate with aortic branches which are now called aortic arches

Each pharyngeal arch also has its own nerve supply

Pharyngeal arches are the future neck which develop during weeks 4 and 5

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7
Q

How are aortic branches formed?

A

•Develop from aortic branches and pharyngeal arch arteries

All are not present at the same time, they all terminate at the dorsal aorta

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8
Q

Where do all the aortic arches terminate?

A

The dorsal aorta

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9
Q

What is the fate of arches 1 and 2?

A

The 1st and 2nd arches disappear early, remnant of the 1st arch forms part of the maxillary artery (branch of external carotid a.)

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10
Q

What is the fate of arch 3?

A

The 3rd aortic arch cis the start of the internal carotid a., and is therefore named the carotid arch

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11
Q

What is the fate of arch 4?

A

The 4th right arch forms the right subclavian,

The 4th left arch constitutes the distal part of aortic arch

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12
Q

What is the fate of the 5th aortic arch?

A

The 5th arch either never forms or forms incompletely and then regresses.

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13
Q

What is the fate of the 6th aortic arch?

A

The proximal part of the 6th right arch persists as the proximal part of the right pulmonary artery

The 6th left arch gives off the left pulmonary a. and forms the ductus arteriosus; within 1–3 months, the ductus is obliterated and becomes the ligamentum arteriosum

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14
Q

Summary of the arches

A
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15
Q

Why do most of the great artery anomalies arise?

A

As a result of persistence of aortic arches that normally should regress or regression of arches that normally shouldn’t.

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16
Q

What is aberrant subclavian artery?

A

Right subclavian vein has an abnormal origin on the left side, to supply the arm it must cross the midline behind the trachea and oesophagus which may constrict these organs

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17
Q

What is double aortic arch?

A

Development of right aortic arch as well as left aortic arch, forming a vascular ring around the trachea and oesophagus whuch usually causes difficulty breathing and swallowing

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18
Q

What is PDA?

A

Patent ductus arteriosus: Fails to close after birth (would normally form ligamentum arteriosis)

Early symptoms are uncommon, but in the first year of life include increased ‘work of breathing’ and poor weight gain. An uncorrected PDA may lead to congestive heart failure with increasing age.

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19
Q

What is coarctation of the aorta?

A

Congenital condiditon

Aorta is narrow usually in the area where the ducts arteriosis inserts

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20
Q

What does coarctation mean?

A

Narrowing

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21
Q

Where are coarctations most common?

A

In the aortic arch

22
Q

What are the three forms of embryonic circulation?

A

Vitelline

Umbilical

Cardinal

23
Q

What do the vitelline arteries supply in the embryo?

A

The yolk sac

24
Q

In an adult what are the vitelline arteries represented by?

A

Celiac artery - artery of the foregut

Superior mesenteric artery - artery of the midgut

Inferior mesenteric artery - artery of the hindgut

25
Q

What are the umbilical arteries before birth?

A

Paired branches of the dorsal aorta to placenta

26
Q

What happens to the proximal portion and the distal portion of the umbilical arteries before and after birth?

A

Proximal portion - Persists as internal iliac and superior vesical branches (to urinary bladder)

Distal portion - degenerates to form obliterated umbilical arteries & forms medial umbilical ligaments

27
Q

What is the role of the vitelline veins?

A

Carries blood from the yolk sac to the sinus venosus

28
Q

What is the role of umbilical veins?

A

•Originate from chorionic villi of placenta carrying oxygenated blood to the embryo

29
Q

What is the function of the cardinal veins?

A

Drain the body of the embryo

30
Q

What do the viteline veins form?

A

Portal vein

Hepatocardiac (liver to heart) part of the inferior vena cava

Liver sinusoids

Superior mesenteric vein

31
Q

What is the fate of the umbilical veins?

A
  • Right Umbilical vein degenerates completely
  • Left umbilical vein obliterates and forms ligamentum teres (=round ligament) of adult liver (teres = round)
  • Ductus venosus obliterates and forms ligamentum venosum
32
Q

What is the function of the ductus venosus in the foetus?

A

Shunts blood from left umbilical vein directly into the inferior vena cava - allows ozygenated blood from the placenta to bypass the liver

33
Q

What is the function of the cardinal veins?

A

Carry blood from the head and the lower body into the heart.

Ancestors of all intraembryonic vasculature

34
Q

What does the cardinal vein system consist of?

A

• anterior, posterior & common cardinal veins draining to sinus venosus

35
Q

What do the cardinal veins form?

A

•Form vena caval (SVC and IVC) system by anastomosis among the veins

36
Q

What are the venous system abnormalities?

A
37
Q

When does the lymphatic system develop?

A

At the end of the sixth week around main veins

38
Q

What lymphatic components have been developed at the end of the embryonic period?

A

Six primary lymph sacs will be developed

•Lymphatic vessels will join the lymph sacs later

39
Q

What is the normal circulatory transition at birth?

A

Placental circulation to pulmonary circulation

40
Q

How does the ductus venosus change on transition to neonate?

A

Shunts left umbilical vein blood flow directly to IVC: allows oxygenated blood from the placenta to bypass the liver.

Obliterates and forms ligamentum venosum

41
Q

How does the oval foramen change on transition to neonate?

A

Allows blood to enter the left atrium from the right atrium: allows blood to bypass the lungs.

Normally this opening closes at birth. When the lungs become functional at birth, the pulmonary pressure decreases and the left atrial pressure exceeds that of the right. This forces the septum primum against the septum secundum, functionally closing the foramen ovale. In time the septa eventually fuse, leaving a remnant of the foramen ovale, the fossa ovalis.

42
Q

How does the ductus arteriosus change on birth?

A

Originally: Allows blood that still escapes the right ventricle to bypass the lungs.

Ductus is obliterated and becomes the ligamentum arteriosum

43
Q

What is the path of the deoxygenated blood from the aorta?

A
44
Q

What happens to the umbilibal vein?

A

Becomes solid ligamentum teres

45
Q

Which gender is patent ductus arteriosus more common in?

A

More frequent in females

46
Q

What is patent ductus arteriosus associated with?

A

Maternal rubella infection

47
Q

What causes patent ductus arteriosus?

A

Failure of muscular wall to contract, respiratory distress syndrome (low O2) and lack of surfactant in the lungs.

48
Q

In 90% of cases where does coarctation occur?

A

Opposite the ductus arteriosus

49
Q

What are the main theories of cause of coarctication?

A

Incorporation of muscle tissue of descending aorta into arch of aorta (during development). When descending aorta contracts after birth, part of the arch also constricts.

Genetic / environmental factors

50
Q
A