Elderly

Question 1

Principles that reduce drug-related morbidity & mortality

Answer 1

• Only when absolutely needed, use drug.
  -Avoid, if possible, a1-adrenoceptor blockers, drugs with anticholinergic effects, very sedative or long half-life or inhibitors of hepatic metab. enzymes
  -start low, and go slow
  -Don’t treat S.E with another drug
  -Keep therapy simple (one dose between than BID)

Question 2

Covert use of medicine (in foodstuff) in dementia allowed only …

Answer 2

full discussion with MDT
recording
only if in patients benefit

Question 3

does the literature support the use of ginkgo Biloba in cognitive impairment and dementia…

Answer 3

Not much.
But it is safe.

Question 4

What is Huperzine A?

Answer 4

an alkaloid isolated from the chinese her huperzia serrata
Highly selective, reversible ACHE-I

Question 5

literature on Huperzin A for AD?

Answer 5

a meta-analysis showed it led to significant. improvement on MMSE and ADL
Later, this result were replicated

Question 6

literature on Efficacy of saffron (crocus sativus) in AD

Answer 6

supported by meta-analysis and systematic review
on adas-cog and other scales