E3: L25 Discussion Posts

Question 1

T/F: Tumors are composed entirely of homogeneous cells.

Answer 1

F

Question 2

Which of the following is NOT a form of immunotherapy?

A. CAR T cell therapy

B. Immune checkpoint inhibitors

C. Nonspecific medications

D. Polymerase Chain Reaction

Answer 2

D

Question 3

Which of the following is NOT a part of a Chimeric Antigen Receptor?

A. Binding domain

B. Transmembrane domain

C. Apoptotic domain

D. Signaling domain

Answer 3

C

Question 4

what are some strategies to target tumor associated macrophages (TAM)? 5

Answer 4

inhibit with PD-L1 antibody, limit monocyte recruitment, clear TAMs, inhibit TAM activity, promote macrophage phagocytic activity

Question 5

Why do immune checkpoint inhibitors cause side effects?

Answer 5

checkpoint inhibitors cause the immune system to be upregulated in order to kill the cancer, therefore, those immune cells will kill the cancer as well as other healthy cells in that area

Question 6

Define PD-L1

Answer 6

Programmed death- ligand 1

Question 7

Two checkpoint proteins that idententify as tumor immunotherapy targets are….

Answer 7

PD1 and PD-L1

Question 8

CART T cell therapy is made from:

Answer 8

The individuals own T cells. By using the patients own T cells this prevents rejection in the body.

Question 9

Tumor associated macrophages(TAM):
activate what cell and inactive what molecule through what interaction

Answer 9

activate the T reg cells, and inactivate CD8 T cells through PDL/PK1 interaction

Question 10

True/False: Our bodies immune system is constantly killing off potential tumor cells everyday

Answer 10

true

Question 11

What are the three types of immunotherapy designed to treat cancer?

Answer 11

non-specific Immune stimulation, Tcell Transfer, Immune checkpoint inhibitor

Question 12

briefly describe non-specific immune stimulation

Answer 12

drugs that initiate the stimulation of innate lymphocytes. This ramps up the immune response and may help the immune cells recognize and respond to malignant cells.

Question 13

briefly describe Tcell Transfer

Answer 13

: the extraction of T cells from a patient’s blood. The DNA of the T-cells is then edited to make them more effective at eliciting an immune response to a malignant tumor. These lymphocytes are then proliferated ex vivo and then injected back into the patient.

Question 14

briefly describe Immune checkpoint inhibitor

Answer 14

drugs allow both helper and cytotoxic T lymphocytes to recognize and respond to tumor cells that have previously evaded immune checkpoints.