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Immunology > E2: L13 > Flashcards

E2: L13 Flashcards

1
Q

helper T cells activate

A

macrophages, Bcells

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2
Q

activation of T cell requires cell to cell __

A

contact

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3
Q

effector response is dependent on ___ cytokines

A

polarizing

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4
Q

Th1 subset is created by what cytokine

A

IL-12

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5
Q

TH2 subset is created by what cytokine

A

IL-4

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6
Q

each Th subset has distinct ___ cytokine profile and __ distinct activities

A

effector, regulates

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7
Q

Th subsets are distinguished by 3 properties: __ cytokines, master gene regulator, signature set of effector cytokines

A

polarizing

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8
Q

Th subsets are distinguished by 3 properties: polarizing cytokines, master gene regulator, signature set of effector cytokines

A
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9
Q

Th subsets are distinguished by 3 properties: polarizing cytokines, master gene regulator, signature set of effector cytokines

A
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10
Q

helper T cells interact with antigen presenting cell and respond to __ cytokines

A

polarizing

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11
Q

cytokines activate to specify one specific ___ regulation system that produces specific cytokines

A

gene

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12
Q

Treg cells do what function

A

suppress immune response

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13
Q

Th2 cells do what function

A

combats helminth infection, activates eosinophils

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14
Q

TFH cells do what function

A

regulates affinity maturation of germinal center B cells

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15
Q

TH1 cells do what function

A

combats intracellular pathogens, activates macrophages

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16
Q

a naive interacts with a specific antigen presented by a __ cell

A

dendritic cell

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17
Q

what helper cell is the main line response to inflammation

A

Th1

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18
Q

effector cytokines of Th1

A

IFN-gamma, TNF

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19
Q

effector cytokines of Th2

A

IL-4,5,13

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20
Q

effector cytokines of Treg

A

IL-10, TGF-beta

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21
Q

effector cytokines of Tfh

A

Il-4,21

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22
Q

TGF stands for

A

transforming growth factor

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23
Q

effector cytokine of Helper T1

A

IFN-gamma

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24
Q

effector cytokine of Helper T2

A

IL-4,5,13

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25
Q

interferons enhance ___ T cell activity

A

cytotoxic

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26
Q

Helper type 2 mainly deals with ___and ___

A

parasites, alllgeries

27
Q

TH cells may be able to morph into another ___

A

subset

28
Q

TH cell differentiation is ___

A

fluid

29
Q

fluidity among subsets makes definitive establishment of helper T cell lineages ___

A

difficult

30
Q

___ ___ commit T cells to one subset or another

A

master regulators

31
Q

____ suppresses Th2 pathway gene expression

A

T-Bet

32
Q

___ suppresses Th1 pathway gene expression

A

GATA3

33
Q

polarizing cytokines IL-6,21 do ___ of master regulator

A

activation

34
Q

effector cytokines IL4,21 __ B-cell ___

A

promote, differentiation

35
Q

Tfh cells also express CD__L and CXCR__

A

40, 5

36
Q

Tfh cells present a receptor for a chemokine that attracts ___

A

Bcells

37
Q

3 subsets of cytotoxic effector cells

A

CD8+, NKT lymphocytes, NK cells

38
Q

__ and __ are involved in organ transplant rejection

A

CTL, NK

39
Q

NKT stands for

A

Natural killer t lymphocytes

40
Q

cytotoxic effector cells can specify__ cells and abnormal __ cells

A

infected, tumor

41
Q

can cytotoxic effector cells recognize and kill self cells?

A

yes

42
Q

CTL effector cells produce

A

perforins and granzymes

43
Q

NK effector cells produce

A

perforins and granzymes

44
Q

NKT effector cells produce

A

FasL

45
Q

all 3 effector cells can be activated by which effector molecule

A

FasL

46
Q

what effector cell does not produce perforins and granzymes

A

NKT cells

47
Q

all cytotoxic cells must have cell to cell ___

A

contact

48
Q

helper T cells bind to MHC 2 and cytotoxic T cells only bind to ___

A

MHC1

49
Q

phase 2: effector T cells recognize MHC 2 to target and induce cell __

A

death

50
Q

2 pathways of how CTLs kill target cells

A
  1. perforin and pranzyme
  2. Fas-FasL Pathway
51
Q

apoptosis: extrinsic pathway uses a death __.
intrinsic pathway uses perforins and gran. via direct __

A

receptor, contact

52
Q

what stage in CTL mediated killing of a target cell is granzyme released to initiate caspase cascade?

A

2

53
Q

2 types of CTLs are

A

Tc1 and Tc2

54
Q

___ uses perforin and fas-mediated death induction

A

Tc1

55
Q

___ only uses perforin death-induction

A

Tc2

56
Q

CD8+ is activated by ___

A

MHC1

57
Q

for a naive cytotoxic cell to be activated, the dendritic cell must be ___ by a __ cell

A

licensed, Helper T

58
Q

___: Th1 cell tells the ___ cell how to better present.

A

licensing, dendritic

59
Q

To prevent redirection of self-antigens into APC pathways, dendritic cells may need ___

A

license

60
Q

___ cells appear to be the primary cross-presenting cell type

A

Dendritic

61
Q

helper T teaches dendritic cell to activate cytotoxic cells

A
62
Q

1 dendritic cell can activate ___ cells at one time

A

several

63
Q

cross-presentation is best because it allows dendritic cells to be more ___

A

versatile

Immunology (21 decks)

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