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Immunology > E2: L14 - Bcell Maturation > Flashcards

E2: L14 - Bcell Maturation Flashcards

1
Q

B cell development beings in the __ __

A

bone marrow

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2
Q

B cell development is completed in the tissue ___

A

periphery

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3
Q

in b-cells, only __ selection required

A

negative

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4
Q

B-cells have no need for ___ restriction

A

MHC

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5
Q

B-cell development begins in the bone marrow with a hematopoietic __ cell

A

stem

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6
Q

B-cells end up in the ___ to differentiate into transitional B cells to produce a mature B-cell

A

spleen

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7
Q

B cells create a ___ response

A

humoral

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8
Q

Pre-B cell and immature b-cells are in the ___ ___

A

bone marrow

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9
Q

pre-b cells are committed to the __ ___ line

A

b-cell

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10
Q

B-cells change up the genes, so produced receptors can be very ___.

A

diverse

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11
Q

inmature b-cells undergo ___ of cell lines. (negative selection)

A

deletion

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12
Q

negative selection: removes things that are strongly selecting for __-___

A

slef-antigens

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13
Q

b-cell receptors are often Ig__ and Ig__ is added with increased cell maturity.

A

IgM, IgD

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14
Q

when B-cells leave the bone marrow, they express what antibody

A

IgM

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15
Q

___ cells provide support and growth factor to developing cells

A

stromal

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16
Q

SCF stands for

A

stem cell factor

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17
Q

stem cells activate into ___ progenitors that produce Pre-B cells

A

lymphoid

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18
Q

___-b cell stage is when the cell is committed to becoming a B-cell.

A

pre

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19
Q

from pre B cell to B cell is when it leaves the bone marrow to go to the ___

A

spleen

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20
Q

B-cells can be ___ by bone marrow

A

retrained

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21
Q

plasma cells are an ___ bcell

A

effector

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22
Q

mature b-cells can also be called ___ b-cells

A

naive

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23
Q

ID of B-cell stages are done by:
cell-surface markers, transcription factors, Ig gene rearrangements

A
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24
Q

HSC -> CLP this looses the ability to go down the __ line

A

myeloid

25
Q

moving pro B to immature B cell is Interleukin ___

A

7

26
Q

Stromal cells in the bone marrow produce _____ which, upon binding to receptors expressed on developing B cells, stimulates progenitor cell survival, proliferation, and transcription of B cell associated genes.
A: IL-7R
B: STAT5
C: Ikaros
D: PU.1
E: IL-7

A

E: IL-7

27
Q

setting up early b-cell for genetic recombination of Ig genes occurs in the ___

A

nucleus

28
Q

IL-7 is produced by s___cells

A

stromal

29
Q

IL-7 stimulates b-cells to become ___ b-cells

A

immature

30
Q

immature B-cell receptors include only the __ chains

A

heavy

31
Q

Immature B cells in the bone marrow are exquisitely sensitive to __ induction.

A

tolerance

32
Q

B-cell surface receptors are tested against self-___

A

antigens

33
Q

clonal deletion and receptor editing are termed ___ ___ as they occur in bone marrow.

A

central tolerance

34
Q

If a cell is too reactive to self-antigen in negative selection, not all are forced into ___

A

apoptosis

35
Q

B-cell surface receptors can be ___ to not be overly reactive to self-antigens

A

selected

36
Q

___, a state of nonresponsiveness to further stimuli

A

anergy

37
Q

b-cell leaving bone marrow only has ___ on surface (antigen)

A

IgM

38
Q

when a b-cell is in the spleen, they differentiate into transitional b-cells that are ___.

A

subsets

39
Q

b-cells go through the transition stages in the __ pulp of the spleen

A

white

40
Q

Mature, primary B-2 B-cells migrate from spleen to ____ follicles

A

lymphoid

41
Q

primary B-___ B-cells respond to antigens with T-cell help by producing antibodies

A

2

42
Q

B-2 cells half-life is approx. ___ months

A

4.5

43
Q

b-cells have variable region ___

A

diversity

44
Q

B1 b-cells are constantly regenerated outside __ ___

A

bone marrow

45
Q

B__ B-cells secrete antibodies even in absence of antigen stimulation

A

1

46
Q

B1 B-cells populate in __ and __ cavityies

A

pleural, peritoneal

47
Q

B_ B-cells have “natural antibodies”

A

1

48
Q

___ B-cells are specialized for blood-borne Ag recognition

A

MZ

49
Q

MZ-bcells have a higher ___ for self-antigens than the other subtypes of B-cells

A

affinity

50
Q

Which of these is NOT a characteristic of B-2 B cells?
A: dependent on IL-7
B: highly diverse V region
C: develop into memory cells
D: found in peritoneal and pleural cavities
E: form from HSCs in the bone marrow

A

D

51
Q

both B and T cell developmental pathways have gene ___

A

rearrangement

52
Q

both B and T cell developmental pathways have ___ selection against self-antigens

A

negative

53
Q

both B and T cell developmental pathways produce ___ of cells with discrete function

A

subsets

54
Q

differences in B and T cell developmental pathways is their location of maturation and screening
B: thymus
T: bone marrow and spleen

A
55
Q

does negative selection occur in both b and T cells or only in B cells?

A

only b cells

56
Q

_ cells require antigen prevention

A

T

57
Q

__ cells require T-cell help and secrete antibodies

A

B

58
Q

APC stands for ______ and is what stimulates a T cell

A

antigen presenting cells

59
Q
A

Immunology (21 decks)

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