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Immunology > E2: L18 > Flashcards

E2: L18 Flashcards

1
Q

The IgG antibody is involved in 5/6 antibody-mediated effector functions. Which ones are they?

A

Neutralization, Agglutination, Opsonization, Complement activation, and ADCC

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2
Q

Name the 6 antibody-mediated effector functions.
NOAADC

A

Neutralization, Opsonization, Agglutination, ADCC, and Degranulation, Complement activation

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3
Q

The IgA antibody is involved in 2/6 antibody-mediated effector functions. Which ones are they? NC

A

Neutralization and Complement activation

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4
Q

The FC receptor is the part of the antibody that is the base of the Y and remind __

A

constant

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5
Q

epitope is the __ part of the molecule that fits with the ___

A

antigenic, paratrope

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6
Q

The IgM antibody is involved in 5/6 antibody-mediated effector functions. Which ones are they?: NAOCA

A

Neutralization, Agglutination, Opsonization, Complement activation, and ADCC

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7
Q

ADCC is ____ through cells that are stimulated to do so.

A

apoptosis

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8
Q

___ is apoptosis through cells that are stimulated to do so.

A

ADCC

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9
Q

IgE is invloed in 1/6 antibody-mediated functions. Which one is it?

A

Degranulation

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10
Q

antibodies can bind in __ and __ regions

A

variable, constant

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11
Q

Fc receptors mediate the ___ ___ of antibodies that bind to the Fc regions of antibodies.

A

receptor functions

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12
Q

____ receptors are the bridge between innate and adaptive

A

Fc

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13
Q

____ receptors on epithelial cells are used to take IgA from blood and put on surface of musoca to protect it. this is called ___

A

Fc, transmicrosis

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14
Q

Fc receptors are members of the ___ superfamily

A

Immunoglobulin

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15
Q

using Fc Receptors allows for __-__ immune cells and bridges the cellular and __ immune systems

A

non-specific, humoral

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16
Q

Multiple FcRs (blue) need to be accessory ___ (green) to initiate a signal.

A

polypeptides

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17
Q

The FcR signal may be positive (___ effector function) or negative (____ effector function).

A

enhancing, inhibiting

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18
Q

The signal may be ____ (enhancing effector function) or ___ (inhibiting effector function).

A

positive, negative

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19
Q

the ___ receptor of the ___ chain is where you bind to the Fc receptor.

A

constant, heavy

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20
Q

1st class of Fc-gamma receptors bind to which Ig

A

IgG

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21
Q

main mediators of antibody function in the body is done by Fc - ____

A

Fc-gamma

22
Q

name few cells that express the Fc-gamma receptor? MGN

A

macrophages, granulocytes, NK cells

23
Q

Fc-gamma is the main mediator of antibody function in the body because it binds to what Ig

A

IgG

24
Q

activating and inhibiting gamma-receptors that will induce what 3 things

A

phagocytosis, degranulation, ADCC

25
Q

the gamma receptor can induce phagocytosis if expressed by what cell

A

macrophage

26
Q

the gamma receptor can induce degranulation if expressed by what cell

A

granulocytes

27
Q

the gamma receptor can induce ADCC if expressed by what cell

A

NK Cells

28
Q

IgE has two subtypes on FcR receptors. they are most commonly associated with ___ symptoms

A

allergy

29
Q

upon exposure to an allergen, it causes the ___ cell to produce IgE antibodies

A

plasma

30
Q

upon exposure to an allergen, it causes the plasma cell to produce ___ antibodies

A

IgE

31
Q

FcR-IgA are expressed by a variety of ___ cell lines

A

myeloid

32
Q

myeloid cells include the following 4 cells: MMGD

A

monocytes, macrophages, granulocytes, dendritic cells

33
Q

serum IgA is slightly different than IgA bound to the tissues.

A

inhibitory

34
Q

Fc-IgA Contributes to pathogen destruction by triggering ___ and ___.

A

ADCC and phagocytosis

35
Q

ADCC stands for

A

Antibody dependent cellular cytotoxicity

36
Q

FcuR is expressed by what cell

A

neutrophils

37
Q

FcuR has a higher affinity for which Ig

A

IgM

38
Q

polyIgRecepotor can respond to ___ antibody types, expressed by ___ cells

A

multiple, epithelial

39
Q

name of the FcRn

A

neonatal Fc Receptor

40
Q

FcRn is related to what MHC class

A

1

41
Q

Which is the most diverse group of Fc receptors?
A. PolyIgR
B. FcγR
C. FcRn
D. FcεR
E. Fcα/µR

A

B

42
Q

___ cells encounter Ag, bind it, and become activated.

A

B

43
Q

After receiving T-cell help, B cells differentiate into ____-___ plasma cells.

A

Antibody-secreting

44
Q

TCRs, BCRs, FcRs, MHC molecules belong to the ___ superfamily

A

immunoglobulin

45
Q

Fc–Fcγ receptor (FcγR) interactions drive pleiotropic effector functions that limit viral ___ and provide potent antiviral ___

A

replication, protection

46
Q

Ab bind Fc receptors expressed by other immune cells or epithelial/endothelial cells is an Immune ___ response

A

effector

47
Q

the immune effector response contains B or T cells?

A

B

48
Q

TCRs can’t bind to antibodies directly; Ag must be presented on MHC molecule. ___ molecules are required for cell signaling

A

CD3

49
Q

antigen receptors of B and T lymphocytes are made from distinct sets of proteins but are similarly constructed. this is because they the same gene has undergone ___

A

recombination

50
Q

___-___ enhance TCR signal

A

Co-receptors

51
Q

Some receptors of this cell inhibit cellular response

A

lymphocyte

Immunology (21 decks)

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