E2: L18 Flashcards
The IgG antibody is involved in 5/6 antibody-mediated effector functions. Which ones are they?
Neutralization, Agglutination, Opsonization, Complement activation, and ADCC
Name the 6 antibody-mediated effector functions.
NOAADC
Neutralization, Opsonization, Agglutination, ADCC, and Degranulation, Complement activation
The IgA antibody is involved in 2/6 antibody-mediated effector functions. Which ones are they? NC
Neutralization and Complement activation
The FC receptor is the part of the antibody that is the base of the Y and remind __
constant
epitope is the __ part of the molecule that fits with the ___
antigenic, paratrope
The IgM antibody is involved in 5/6 antibody-mediated effector functions. Which ones are they?: NAOCA
Neutralization, Agglutination, Opsonization, Complement activation, and ADCC
ADCC is ____ through cells that are stimulated to do so.
apoptosis
___ is apoptosis through cells that are stimulated to do so.
ADCC
IgE is invloed in 1/6 antibody-mediated functions. Which one is it?
Degranulation
antibodies can bind in __ and __ regions
variable, constant
Fc receptors mediate the ___ ___ of antibodies that bind to the Fc regions of antibodies.
receptor functions
____ receptors are the bridge between innate and adaptive
Fc
____ receptors on epithelial cells are used to take IgA from blood and put on surface of musoca to protect it. this is called ___
Fc, transmicrosis
Fc receptors are members of the ___ superfamily
Immunoglobulin
using Fc Receptors allows for __-__ immune cells and bridges the cellular and __ immune systems
non-specific, humoral
Multiple FcRs (blue) need to be accessory ___ (green) to initiate a signal.
polypeptides
The FcR signal may be positive (___ effector function) or negative (____ effector function).
enhancing, inhibiting
The signal may be ____ (enhancing effector function) or ___ (inhibiting effector function).
positive, negative
the ___ receptor of the ___ chain is where you bind to the Fc receptor.
constant, heavy
1st class of Fc-gamma receptors bind to which Ig
IgG
main mediators of antibody function in the body is done by Fc - ____
Fc-gamma
name few cells that express the Fc-gamma receptor? MGN
macrophages, granulocytes, NK cells
Fc-gamma is the main mediator of antibody function in the body because it binds to what Ig
IgG
activating and inhibiting gamma-receptors that will induce what 3 things
phagocytosis, degranulation, ADCC
the gamma receptor can induce phagocytosis if expressed by what cell
macrophage
the gamma receptor can induce degranulation if expressed by what cell
granulocytes
the gamma receptor can induce ADCC if expressed by what cell
NK Cells
IgE has two subtypes on FcR receptors. they are most commonly associated with ___ symptoms
allergy
upon exposure to an allergen, it causes the ___ cell to produce IgE antibodies
plasma
upon exposure to an allergen, it causes the plasma cell to produce ___ antibodies
IgE
FcR-IgA are expressed by a variety of ___ cell lines
myeloid
myeloid cells include the following 4 cells: MMGD
monocytes, macrophages, granulocytes, dendritic cells
serum IgA is slightly different than IgA bound to the tissues.
inhibitory
Fc-IgA Contributes to pathogen destruction by triggering ___ and ___.
ADCC and phagocytosis
ADCC stands for
Antibody dependent cellular cytotoxicity
FcuR is expressed by what cell
neutrophils
FcuR has a higher affinity for which Ig
IgM
polyIgRecepotor can respond to ___ antibody types, expressed by ___ cells
multiple, epithelial
name of the FcRn
neonatal Fc Receptor
FcRn is related to what MHC class
1
Which is the most diverse group of Fc receptors?
A. PolyIgR
B. FcγR
C. FcRn
D. FcεR
E. Fcα/µR
B
___ cells encounter Ag, bind it, and become activated.
B
After receiving T-cell help, B cells differentiate into ____-___ plasma cells.
Antibody-secreting
TCRs, BCRs, FcRs, MHC molecules belong to the ___ superfamily
immunoglobulin
Fc–Fcγ receptor (FcγR) interactions drive pleiotropic effector functions that limit viral ___ and provide potent antiviral ___
replication, protection
Ab bind Fc receptors expressed by other immune cells or epithelial/endothelial cells is an Immune ___ response
effector
the immune effector response contains B or T cells?
B
TCRs can’t bind to antibodies directly; Ag must be presented on MHC molecule. ___ molecules are required for cell signaling
CD3
antigen receptors of B and T lymphocytes are made from distinct sets of proteins but are similarly constructed. this is because they the same gene has undergone ___
recombination
___-___ enhance TCR signal
Co-receptors
Some receptors of this cell inhibit cellular response
lymphocyte
