Digestive Glands 2 Flashcards
what is the parenchymal cell of liver?
hepatocyte - liver is the second largest organ in the body!
what is Glisson’s capsule?
the capsule of the liver that subdivides the liver into lobes and lobules
what is special about the portal v. contents?
nutrient laden (heavy) blood from the alimentary tract and spleen
what is porta hepatis aka portal triad?
region where the hepatic a. and portal v. ENTER
hepatic ducts LEAVE
what do the sublobular veins collect blood from?
the central v. of each classical liver lobule
what is the hepatic v. made up of?
union of many sublobular veins
what are the three types of liver lobules
classical = hexagonal
portal = triangular
liver acinus of Rappenport = diamond
what does the portal area (triad) contain?
branches of the portal v.
hepatic a.
bile duct
lymph vessel
what composes the bulk of the lobule?
plates of hepatocytes
where are bile canaliculi? what do they do?
between neighboring heptaocytes
convey bile to canals of Herring
what do the canals of Herring do?
deliver bile ducts in portal areas at the periphery of the classical lobule
what re sinusoids? waht do they do?
endothelial-lined spaced between neighboring plates of hepatocytes
they recieve blood from the vessels in teh portal areas and dliver it to the central vein
what is interesting about the endothelial cells that line the sinusoids?
large fenestrations - discontinuous
what are Kupffer Cells? what do they do?
present within endothelial lining
phagocytic cells that are derived from moncytes
what is the space of Disse? function?
subendothelial space between liver cells and the lining cells of the sinusoids
exchange material betwen blood stream and hepatocytes
no basal lamina!
what does the space of Disse contain?
stellate - shaped fat storing cells - store vit. A
reticular fibers - maintain arch. of sinusoids
non myelinated nerve fibers
short, blunt Mv of hepatocytes
what is the portal lobules?
triangle - 3 apices are neighboring central v.
portal area in center of triangle
what is the liver acinus of Rappenport?
wtf?
what do hepatocytes have?
rER and sER mitochondria golgi regions lysosomes and peroxisomes - repped lipid droplets glycogen
Proteins produced by hepatocytes are synthesized in the rough endoplasmic reticulum (RER),
explains why hepatocyte lesions or starvation lead to a decrease in the amounts of albumin, fibrinogen, and prothrombin in a patient’s blood.
what makes up intrahepatic bile duct?
bile canaliculi
cholangioles
canals of herring- liine by low cuboidal cells
bile ducts - lined by single cuboidal cells
what are hepatic bile ducts?
recieve bile from the main ducts of the liver
major ducts are right andleft
what is teh exocrine function of the liver?
prduction of bile
what is bile made of?
bilirubin, bile acids, cholsterol, phospholipids, ions and water
what is the endocrine secretions of the liver?
glucose
plasma proteins - prothrombin, fibrinogen, albumin, factor 3, LDL
what does the liver do in detoxification?
liver ditoxifies various drugs and toxins
where does IgA uptake in teh liver occur?
from blood steam occurs at space of Disse
what type of cells are in the mucosa of gallbladder?
simple columnar epitheliam and rich vascular LP
what is teh sinuses of Rokitansky-Ashoff
deep invaginations of epithelium that may extend into the perimuscular CT
what are the ducts of Luschka
non functional, blind ending ducts in the vacinity of the neck of gall bladder
what direction does the flow of blood go?
from periphery to central vein
what direciton does the flow of bile flow?
from hepatocytes to bile canalicui to bile duct in periphery
where do you find mV?
bile canaliculi and space of Disse
what does the classical lobule show?
flow of blood
what does the portal lobule show?
flow of bile
what does the rappenport show?
flow of blood - connects 2 classical lobules = 2 central v. + 2 portal areas
what goes on in zone 1
gets the most blood and toxins
what goes on in zone 3
gest the least blood, less toxin
how many nuclei do hepatocytes have?
usually 2 - liver can regenerate!
what uses sER in hepatocytes?
glycogen - syntehsis and degradation
what uses rER in hepatocytes?
amino acids – protein synthesis – albumin, prothrombin, fibrinogen, lipoprotein
