Connective Tissue Flashcards
CT - overview (location, contents, embryologic background)
in the ECM, contain fibers + ground substance + cells, arise from mesenchyme
What makes up the ECM?
fibers (collagen, reticular, elastic) and ground substance (glucosaminoglycans, glycoproteins, proteoglycans)
type I collagen
most common, found in lamina propria, dense CT, bone, tendon, dentin and skin
type II collagen
hyelin and cartilage
Type III collagen (reticular fibers)
found in organs that expand and recoil - spleen, liver, lymphoid tissue , small blood vessels, early wound healing -
type IV collagen
basement membrane
Type V collagen
amnion and chorion of fetus, muscle and tendon sheaths
steroids - what do they inhibit?
biosynthesis of collagen - cream thins out the skin
fibroblasts
make and break collagen
what secretes Type III collagen (reticular fibers)?
secreted by fibroblasts, smooth muscle and reticular cells
elastic fibers - composition
oxytalan, elaunin, elastin - found in elastic arteries, aorta branches, vocal chords, ear lobes
elastic fibers - synthesis
by fibroblasts and smooth muscle cells
3 types of CT cell types
resident, transcient, fibroblast
adipose cells - define unilocular, multilocular
unilocular = 1 lipid droplet, multilocular = many lipid droplets
what special feature does macrophages have?
pseudopodia = extension of cytoplasms = movement!
what do mast cells do to stains
metachromasia
what do plasma cells nuclei look like?
soccer ball!
what makes up the ground substance
glycosaminoglycans = sulfats, glycoproteins = “-ins”, proteoglycans =”-cans”
how are GAGs produced?
hyaluronic acid
how is loose CT identified?
lots of GS, few fibers, some blood vessels
how is Dense CT identified?
lots of fibers, little GS
