Development of the heart Flashcards
the receiving chambers of the heart
Atria
The ejecting chambers of the heart
Ventricles
what kind of blood is in the right side of the heart
Deoxygenated blood pumped to lungs
what kind of blood is in the left side of the heart
receives oxygenated blood and pumps to body
the adult heart
neonatal heart
how early is the cardiovascular system able to be functional
one of the first systems
Stages of heart development
Cardiac Crescent
Heart Tube
Pre-septated looped heart
Four chambered heart
Flow through the heart tube
Caudal to cranial
last step of heart development
septated into 4 chambers
migration of progenitor heart cells
Migrate through primitive streak into splanchnic layer of lateral plate mesoderm
the 1st sign of heart formation
solid horseshoe-shaped cluster of cells
the solid horseshoe-shaped cluster of cells that is the 1st sign of heart formation
Primary heart field
organization of the primary heart field
Medial: eventual aorta
in-betwen: Ventricles
Lateral: atria
when blood vessels arise from blood islands
Vasculogenesis
when blood vessels sprout from existing vessel
Angiogenesis
what happens in Vasculogenesis
Mesoderm cells cluster together around hemangioblasts to eventually form a tube
where does Vasculogenesis occur
in the embryo
Parts of Heart Development
Establishment and patterning of primary heart field Heart tube formation and positioning Cardiac loop formation Sinus venosus Partitioning of the heart
where does the heart originally form in respect to the brain
Ontop and infront of the brain
how does the heart get into the correct position
Due to cranial caudal folding
what forms the endocardial tubes
the uniting of blood islands
number of endocardial tubes before folding
2 (one on the right and one on the left
what happens while the endocardial tubes form
other blood island appear to form the pair of longitudinal dorsal aortae
roll of dorsal aorta
outflow of blood to the body
what causes the endocardial tubes to come close together to enventuall fuse
Lateral folding
do dorsal tubes fuse due to lateral folding
no
relation of heart tube to septum transversum (precursor to diaphram)`
Slightly causal
relation of heart tube to Pericardial cavity`
VEntral
relation of heart tube to oropharyngeal membrane (opening to oral cavity)
Cranial
how does the Heart tube eventually get below the brain
Cranial folding around teh opophyngeal membrane pushes brain up and heart down
Flow of the heart tube
Caudal to cranial possition
Flow through heart tube dilations
Sinus Venosus Primitive atrium Primitive ventricle Bulbus cordis Truncus arteriosus
what connects the primitive atrium and the primitive ventricle
Atrioventricular canal
what part of the heart tube forms part of the right atrium
Sinus VEnosus
what part of the heart tube forms part of the left atria
Primitive atrium
what part of the heart tube forms forms inlet of the ventricles
Primitive Ventricles
what part of the heart tube forms outlet of the ventricles
Bulbus Cordis
what part of the heart tube forms the aorta and pulmonary artery
Truncus arteriosus
how does the Tubular heart loop
Right handed looping
what does the looping of the tubular heart form
A U-shaped loop that results in a heart with an apex pointing left
Travel of the Primitive ventricle during Cardiac looping
Moves Ventral and to the right
travel of the atrial region during cardiac looping
Moves dorsally and to the left
Flow of blood after Cardiac Looping
Flow from caudal to cranial
is blood flow interrupted due to heart looping
Nope! Uninterrupted through different parts
where does Sinus Venosus receive Venous blood
From left and right sinus horns
where does each sinus horn receive venous blood from
Vitelline vv (medial) Umbilical vv (midline) Common cardinal vv (lateral)
what forms the Common cardinal vv
anterior and posterior cardinal vv
what brings oxygenated blood into spinus Venosus
the 2 umbilical veins (blood from the mom)
what happens to blood flow in the sinus venosus during remodeling
Blood flow gradually shifts to the right side
size of the right and left horn of the sinus venosus after remodeling
Right horn is larger than left horn
what does the Left sinus horn become after remodeling
Oblique veins of the left atrium
Coronary sinus
where does the Right side of the senius Venosus go
Incorporated inot the right caudal/dorsal wall of developing atrium
what does the right side of sinus venosus displace
The original right half of the primitive atrial wall farther to the right
The portion of the atrium consisting of the incorporated sinus venosus
Sinus venarum
what partitions in the heart
Atria
Ventricles
Outflow tracts
what grows from the roof of the atrium and hooks down towards the floor (inferior)
Septum Prima
where does septum prima grow towards
The suptum cusion
Does the septum Prima complete separate the Atriums
No, theres still a big hole connecting the two
What is the Hole that connects the two atrium when the septum prima forma
Foramen primum
what happens once the septum primum hits the septal cusion
separtes the two atrium, but theyre still concected with flow in between them
what allows flow between atrium once the septum primum is fully formed
Foramen secundum (foramen primum is gone)
the more dense part that separates the atriums after the septum primum
Septum secundum
Growth of septum secundum
Grows from the roof of the atrium to the floor(endocardial cusion) to the right of the Septum primum
what is the inferior opening of the septum secundum while it continues to grow
foramen ovale
what septum opening of the atria is maintained
The foramen ovale
what does Foramen ovale bceome in the neonatal heart
Fossa ovalis
when do the 4 AV endocardial cushions form
near the end of week 4
where does the 4 AV endocardial cushions form
on each side of the atrioventricular canal
what separates the R and L atrioventricular canals
Swellings of the superior and inferior endocardial cushions to the point that they fuse together
What eventually happpens to the Primary Ventricles
Begin to expand
what do the medial walls of the PRimitive ventricles do
MErge together to form the muscular interventricular septum
location of the interventricular foramen
Above the muscular interventricular septum
what closes the interventricular foramen
Outgrowth of endocardial cushions
complete closuure of the interventricular foramen forms
The membranous part of the interventricular septum
Formation of the 1st outflow tracts of the heart
Week 5, neural crest cells migrate into truncus arteriorsus and bulbus cordis
what does Truncus arteriorsus and bulbus cordis form
Truncal ridges and bulbar ridges
without neural crest cells in the outflow tracts, what does not happen
No seperation of the outflow tracts
travel of the Truncal and bulbus ridges
spiral from wall to the outflow portion (180 degrees)
SPiraling of the Truncal and Bulbus ridges results in forming what when they fuse
A spiral aorticopulmonary septum
INferior growth of Truncal and Bulbus ridges contributes to
A portion to membranous IV
What does Spiralling of the outflow tracts of the heart lead to
why the right ventrical ejects blood out to the left and anterior
why the left ventrical ejects blood behind and to the right
flow of blood in the fetus heart
blood flow into the right atrium (both oxygenated and deoxygenated)
Oxygenated blood travels to Left atrium via foramen ovale
then leave via left ventricle