Criptococosis (9) Flashcards

1
Q

Datos pivote

A
  • Px con VIH, cancer hematologico, transplantados
  • Fiebre
  • Focalizacion neurologica
  • Brundzinski
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2
Q

Donde se adquiere clásicamente

A

Heces de paloma

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3
Q

CD4 con riesgo y se indica profilaxis

A

< 100

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4
Q

Agente profiláctico

A

Fluconazol o itraconazol

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5
Q

Dx

A
  • Tincta china (o metanamina Grocott)
  • Cultivo
  • LCR
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6
Q

Características del LCR

A

Linfocitos e hiperproteinorraquia

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7
Q

Tx

A

Anfotericina B + flucitosina 2 semanas, seguido de fluconazol 10 semanas y después tratamiento de mantenimiento por al menos un año con fluconazol
- Se considera incurable a menos que inmunidad mejore

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8
Q

Mecanismo de acción de imidazoles

A

Inhibición de la 14-α-esterol desmetilasa alterando la biosíntesis de ergosterol para la membrana citoplásmica

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