CP Heart Development and Defects Flashcards
What arises from the primary heart fields?
Left and right atria, as well as the left ventricle
Almost all of the heart comes from what layer of embryonic tissue?
Splanchnic mesoderm
From what structure do the secondary heart fields develop?
Pharyngeal arches
What three pharyngeal arches do the neural crest cells migrate through?
3, 4, and 6
What gives rise to the aorticopulmonary septum?
Neural Crest cells
What mediates movement of neural crest cells?
Retinoic acid / HOX genes / NF-1 / PAX-3
When are the septation events of the heart occurring?
4th week to 8th week
When do we see the sinus venosus?
Day 23
Where do the smooth parts of the adult heart arise from?
Where does the sinus venarum specifically come from?
The sinus venosus
Right horn of the sinus venosus
Where does the coronary sinus come from?
Left horn of the sinus venosus
What structures come from the right horn of the sinus venosus?
Openings for the superior and inferior vena cava
Opening for the coronary sinus
Sinus venarum
Christa terminalis
What specific structure gives rise to the crista terminalis?
The right sinoatrial valve’s cranial portion
When does the heart first begin to beat?
Day 22 (week 4)
What is the dorsal mesocardium?
A mesentary, drived from the splanchnic layer of the lateral plate mesoderm
What is the most posterior structure of the heart?
The left atrium
When do septation events occur?
From week 4 to 8
What structure comes from the left horn of the sinus venosus?
Coronary sinus
What four structures come from the right horn of the coronary sinus?
Orifice for the coronary sinus
Orifice for the superior / inferior vena cava
Sinus venarum
Crista terminalis
What structures come from the caudal and rostral part of the right sinuatrial valve?
The caudal part becomes the valve of the coronary sinus and most of the valve of the inferior vena cava.
The cranial part becomes the crista terminalis
What embryologic layer forms the muscular interventricular septum?
Splanchnic layer of the lateral plate mesoderm
What structures are given rise to by the bulbus cordis on the right and left side of the heart?
Right: Conus arteriosus
Left: Aortic vestibule
What embryological layer gives rise to the membranous interventricular septum?
Neural crest cells (right and left bulbar ridge)
(and the endocardial cushion is made from splanchnic mesoderm)
What cavities of the heart are separated by the membranous interventricular septum?
Right and left ventricle
AND
Right atrium and left ventricle
What embryological layer are the semilunar valves made from?
What primitive structures become the semilunar valves?
Neural crest cells and mesoderm
Ventral and dorsal valve swellings
