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CPR Exam 1 > CP Great Vessels Embryology > Flashcards

CP Great Vessels Embryology Flashcards

1
Q

When does vasculogenesis begin?

A

By the end of the third week

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2
Q

What are the first to loci for the formation of blood islands?

A

Extraembryonic splanchnic mesoderm (around the yolk sac)

Aortic gonad mesonephric region (AGM)

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3
Q

What arises from aortic arch 1?

A

Maxillary

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4
Q

What arises from aortic arch 2?

A

Stems of the stapedial arteries

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5
Q

What arises from the aortic sac?

A

Brachiocephalic artery

Base of the arch of the aorta

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6
Q

What arises from aortic arch 3?

A

Internal carotid

Common carotid

External Carotid

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7
Q

What arises from aortic arch 4?

A

Left: medial portion of the arch of the aorta

Right: proximal right subclavian (distal part comes from the 7th segmental artery, and another part comes from the dorsal aorta)

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8
Q

What arises from arch 6?

A

Pulmonary arteries

Left: Distal ductus arteriosus

Right: Distal portion degenerates

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9
Q

What arises from the 7th segmental artery?

A

Left: Entire left subclavian

Right: Distal part of the right subclavian (the proximal part came from arch 4, and another part comes from the dorsal aorta)

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10
Q

What arises from the dorsal aorta?

A

Right: Portion of the right subclavian (the proximal part comes from arch 4 and the distal part from 7th segmental artery)

Left: Descending aorta

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11
Q

What vessel brings oxygenated blood from the placenta to the newborn?

A

The left umbilical vein

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12
Q

What structure allows placental blood to bypass the fetal liver?

A

The ductus venosus

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13
Q

What do we call the neonatal remnant of the left umbilical vein?

A

The ligamentum teres (round ligament of the liver)

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14
Q

What is the embryological structure that becomes the ligamentum venosum?

A

Ductus venosus

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15
Q

What signaling molecule assists in the closure of the ductus arteriosus?

What signaling molecule can keep it open?

A

Bradykinin

Prostaglandins

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16
Q

What causes a double aortic arch?

A

Persistence of the distal portion of the right dorsal aorta (proximal portion makes a part of the right subclavian like it’s supposed to - but then the distal portion remains.

s/s-dysphagia and dyspnea

17
Q

What causes an interrupted aortic arch?

A

Abnormal disintegration of both of the 4th aortic arch arteries

18
Q

What genetic defect is often associated with an interrupted aortic arch?

A

DiGeorge Syndrome (22q11 deletion)

19
Q

Which upper extremity (right or left) always gets blood in patients with an interrupted aortic arch?

A

The right side upper extremity.

Left side sometimes does, sometimes doesn’t. Lower extremity depends on the ventricular septal defect and patent ductus arteriosus.

20
Q

What is the function of the vitelline veins?

A

Returning blood from the yolk sac and liver to the heart.

21
Q

Proximal to the heart, which vitelline vein degenerates, and which persists?

A

Left vitelline degenerates near the heart, but the right vein persists

22
Q

What are the fates of the right and left vitelline veins in the liver?

A

Right gives rise to the hepatic vein (part of inferior vena cava)

Right and Left both give rise to the portal vein

23
Q

What part of which umbilical vein persists to bring O2 rich blood back from the placenta?

A

The distal portion of the left umbilical vein

24
Q

What blood vessels arise from the anterior cardinal veins?

A

Right: Superior vena cava

Left: Brachiocephalic Vein

25
Q

What blood vessels arise from the posterior cardinal veins?

A

Subcardinal veins

Supracardinal veins

Root of the azygos vein

Common iliac vein

26
Q

What defect results in a left superior vena cava?

A

Obliteration of the right common cardinal vein and the proximal part of the right anterior cardinal vein.

(Thus the superior vena cava has to come from the left, since the right is gone)

27
Q

What defect results in a double superior vena cava?

A

Failure of the left brachiocephalic vein to form, resulting in it forming another vena cava.

28
Q

Where do left sided superior vena cavas drain?

A

Into the coronary sinus.

29
Q

What structure gave rise to the following segment of the inferior vena cava:

Hepatic

A

Hepatic veins and sinuses

Right Vitelline

30
Q

What structure gave rise to the following segment of the inferior vena cava:

Pre-renal

A

Right Subcardinal

31
Q

What structure gave rise to the following segment of the inferior vena cava:

Renal

A

Subcardinal-supracardinal anastomosis

32
Q

What structure gave rise to the following segment of the inferior vena cava:

Postrenal

A

Right Supracardinal

33
Q

S/S of a Patent Ductus Arteriosus

A

LV hypertrophy

pulmonary congestion

CHF

treat with indomethacin or surgery

Increased risk with maternal rubella infections

34
Q

What is coarctation of the aorta and what is it associated with?

A
  • aorta is abnormally constricted.
  • A postductal coarctation is found distal to the origin of the left subclavian artery and inferior to the ductus arteriosus.
  • It is clinically associated with increased blood pressure in the upper extremities, lack of pulse in femoral artery, high risk of both cerebral hemorrhage and bacterial endocarditis.
  • A preductal coarctation of the aorta in which the constriction is located superior to the ductus arteriosus occurs less commonly.

Assx with Turner’s Syndrome

35
Q

Abberant Origin of the Right Subclavian A.

A
  • occurs when right aortic arch 4 and the right dorsal aorta cranial to the seventh intersegmental artery abnormally regress.
  • As development continues, the right subclavian artery lies on the left side just inferior to the left subclavian artery.
  • The right subclavian artery must therefore cross the midline posterior to the trachea and esophagus to supply the right arm.
  • This anomaly may constrict the trachea or esophagus. However, it is generally not clinically significant. (possibly dysphagia )
36
Q

Where is most of the SVC blood directed into in the fetus?

A

into the RV

(90% from RB enters aorta via DA, 10% enters lungs)

CPR Exam 1 (31 decks)

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