Clotting Cascade Flashcards

1
Q

What are the steps from tissue injury to the common pathway for the extrinsic pathway?

A

Tissue Injury

Factor III (Tissue Factor) released

Tisue factor turns Factor VII into Factor VIIa

Factor VIIa turns Factor X into Factor Xa

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2
Q

Which factors are vitamin K dependent?

A

Factors II, VII, IX, X

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3
Q

What all makes up prothrombinase?

A

Factor Va

Factor Xa

Ca2+

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4
Q

What is the role of thrombin in the polymerization of fibrin?

A

It activates Factor XIII, which crosslinks fibrin polymers to form “stable fibrin.”

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5
Q

Thrombin catalyzes the activation of which two factors?

A

Factor V and Factor VIII

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6
Q

What lab test primarily tests the extrinsic and common pathway?

What factors of the extrinsic pathway are tested?

A

Prothrombin time

Just VII

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7
Q

What lab test primarily tests the intrinsic and common pathway?

A

Activated partial thromboplastin time

(Remember that kaolin is used for the negative surface in activated partial thromboplastin time tests.)

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8
Q

What test measures the activity of Heparin?

A

Activated partial thromboplastin time

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9
Q

Which factors are inhibited by heparin?

A

II, IX, and Xa

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10
Q

Which factors are inhibited by coumadin?

A

The ones that use Vitamin K

II, VII, IX, X

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