Connective Tissue Flashcards
connective tissue….
transport material (blood), structure (bone), no contact with environment
characteristics
Usually are rich in blood supply, with a few exceptions, such as cartilages, tendons and ligaments.
Are made of many types of cells
There is a great deal of non-cellular, nonliving materials (extracellular matrix)between the cells of connective tissues.
Ground substance: Interstitial fluid, cell adhesion proteins and proteoglycans.
Fibers: Collagen, elastic and reticular fibers
3 classifications
proper, fluid, supportive
connective tissue proper:
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Adipose, mesynchimal, melanocyte, macrophage, microphage, mast cells, lymphocyte, fibrocyte, fibroblasts
fibroblasts
The most abundant cell type:
found in all connective tissue proper
secrete proteins and hyaluronan (cellular cement)
The mitotic activity can be regulated by growth factor when tissue needs more fibroblast, e.g. organ injury
Macrophages are
Large, amoeba-like cells of the immune system:
eat pathogens and damaged cells (by phagocytosis)
fixed macrophages stay in tissue
free macrophages migrate
macrophages can be either _____ or _____
fixed or free
melanocytes
synthesize and store melanin
mast cells originate from
bone marrow
lymphocytes
T, B natural killer specific
microphages
phagocytic blood cells
microphages participate in
non-specific immunity
Number of Connective tissue Fibers:
3 types; collagen, elastic, reticular
collagen is the
Most abundant in human body
Major product of fibroblasts
Fibrillar collagens (I and II), sheet-forming collagens (IV) and linking/anchoring collagens (VII)
collagen fibers are
long straight and unbranched (Strong and flexible)
examples of collagen fibers:
tendons, ligaments, parts of bones and blood vessels
Elastic Fibers
Branched, wavy, elastin fibers, returns to original length after stretching, formed by fibroblasts
Branched and wavy
Return to original length after stretching
For example, elastic ligaments of vertebrae
reticular fibers
forms networks produced by fibroblasts, thin, needs special stain to be visible, supportive stoma Produced by fibroblasts Form networks Thin Needs special stain to be visible Supportive stroma (supportive network) Parenchyma: Functional part of the organs. E.g. found in spleen and lymph nodes
stroma or parenchyma
supportive and functional part of organs
reticular fibers are usually found in:
collagen III in lymph nodes
connective tissue proper is:
loose or dense
loose connective tissue is more____ less_____
ground, fibers (i.e. fat)
Dense connective more_____ less_____
fibers ground substance
3 types of Loose
Areolar, Adipose, Reticular
Areolar characteristics
more ground, less fiber, distort without damage elastic fiber
Underneath the epithelium of the skin (papillary layer only)
Epidermis layer, tissue
stratified squamous, epithelium
dermis layers:
papillary, reticular
adipose tissue
contains adipocytes
Subcutaneous and around organs