Component Therapy Flashcards
Component therapy for loss of 25% blood volume and replacement of RBC and plasma volume
Whole blood.
Component therapy for recurrent febrile reactions due to white cell antibodies, CMV transmission reduction, and HLA alloimmunization
Leukoreduced PRBCs (LRPRBC).
Component therapy for plasma protein antibodies, PNH diagnosis, and febrile reactions from leukoagglutinins
Washed RBCs.
Component therapy for reduced exposure to WBCs, platelets, and plasma proteins; long-term storage of rare or autologous units
Frozen/Thawed/Deglycerolized RBCs.
Effect of one unit of PRBC/Whole blood in adults
Increases hemoglobin by 1 g/dL and hematocrit by 3–5%.
Effect of 10–15 mL/kg of PRBC in pediatric patients
Increases hemoglobin by 2–3 g/dL or hematocrit by 6–9%.
Platelet product to correct thrombocytopenia due to decreased function, production, or increased consumption
Random Donor Platelets.
Platelet count increase with random donor platelets transfusion
Increases platelet count by 5,000 to 10,000/µL.
Platelet product for correcting thrombocytopenia in patients with refractoriness to random donor platelets
Single Donor Platelets.
Platelet count increase with single donor platelets transfusion
Increases platelet count by 20,000 to 60,000/µL.
Reason for using single donor platelets in refractoriness cases
Less exposure to foreign antigens due to reduced alloimmunization; more expensive.
Buffy coat method
Hard spin of whole blood, pool buffy coat, soft spin for platelets.
Purpose of agitation
Facilitates oxygen transfer and consumption by platelets.
Corrected Count Increment formula
= Absolute platelet increment/µL × body surface area (m²) / platelets transfused.
Components of Corrected Count Increment
Absolute platelet increment (post transfusion platelet count – pretransfusion platelet count), body surface area (m²), platelets transfused.
